糖皮质激素防治早产儿支气管肺发育不良的进展及争议

摘要: 支气管肺发育不良(BPD)是早产儿最严重的并发症之一，在诸多防治方法中，糖皮质激素的应用目前仍最具争议性。糖皮质激素治疗早产儿呼吸系统疾病早在1957年就有报道。在上世纪90年代糖皮质激素成为BPD预防与治疗的常规用药。因全身糖皮质激素治疗的并发症，自1999年糖皮质激素的使用开始减少。近年来，亦有很多文献对糖皮质激素治疗BPD进行了综述及报道，但结果参差不齐，正负面结果并存。建议临床医师应慎重使用糖皮质激素，并使用可能最低的剂量和最短的疗程。

Study progress and controversy of corticosteroids for prevention and treatment of bronchopulmonary displasia in premature infants

Abstract: Bronchopulmonary dysplasia(BPD)is one of the most serious complications of premature infants.Corticosteroids is the most controversial application among the prevention and treatment of BPD. The application of corticosteroids therapy in premature respiratory system diseases was reported early in 1957. In the 1990s, Corticosteroids become the routine drug of the prevention and treatment of BPD. Since 1999, the use of corticosteroids started to decrease because of the corticosteroids therapy complications. In recent years, there are a lot of literatures on corticosteroids therapy BPD were reviewed and reported, but the results are different. The reports have positive results, also have negative results. So the suggestion is that the clinicians should use corticosteroids cautiously with the lowest dose and the shortest course of treatment possible.