2型糖尿病患者血清CRP及血脂水平变化的研究

目的探讨2型糖尿病（T2DM）患者血清高敏C-反应蛋白（11s—cRP）及血脂水平的变化及其临床意义。方法将280例T2DM患者随机分为代谢综合征（Ms）组及非MS组，应用免疫透射比浊乳胶增强法检测各组血清hs—CRP水平，并检测总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL—C）浓度，以40名健康人作对照。结果T2DM合并代谢综合征（Ms）组及非MS组血清hs—CRP水平分别为（3．95±2．89）mg／L、（2．38±1．53）mg／L，明显高于正常对照组的（0．72±0．53）mg／L，3组两两比较差异有极显著性意义（P〈O．01）。MS组Tc、TG、LDL-c水平比非MS组及对照组高（P〈0．05）。T2DM患者hs—CRP浓度与体重指数、TG、LDL-C呈正相关（r分别为0．634、0．415、0．415，P〈0．05），与HDL-C呈负相关（r=-1．618，P〈0．01）。结论T2DM患者hs—CRP升高及血脂异常可作为预测T2DM并发MS及心血管疾病危险性的重要实验室指标。

Study of change of high sensitive C-reactive protein and lipid level in patients with type 2 diabetes mellitus

Objective To explore the change and clinic significance of serum sensitive c-reactive protein （hs-CRP） and lipid levels in patients with type 2 diabetes mellitus （T2DM）. Methods The concentrations of serum hs-CRP and lipid （TC, TG,HDL-C and LDL-C） in 155 T2DM complicated with metablolic syndrome （MS） and 125 with no MS and 40 normal people. Results The Level of hs-CRP of DM group with MS was higher （3.95±2.89）mg/l],than that without MS （2.38± 1.53）mg/L and normal people （0.72±0.53）mg/L （P〈0.01=. The levels of TC,TG and LDL-C were higher than that without MS and normal people （P〈0.05）. The level of serum hs-CRP was positively correlated with BMI,TG,and LDL-C （r=-0.634, 0.415,0.415,P〈0.05）, and negatively correlated with that of HDL-C （r= -1.618,P〈0.01）. Conclusions The levels of hs- CRP and lipid in T2DM can be used as the indexes for predict the risk of T2DM complicated with MS and angiocardiopathy.