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| 超氧化物歧化酶对急性胃粘膜损伤的保护作用 | |
| 引用本文： | 马Jin 张春芬. 超氧化物歧化酶对急性胃粘膜损伤的保护作用[J]. 中国药理学通报, 1996, 12(6): 545-548 |
| 作者姓名： | 马Jin 张春芬 |
| 作者单位： | 济宁医学院药理教研室 |
| 摘 要： | 制作不同的动物急性胃粘膜损伤模型，应用外源性超氧化物歧化酶（ＳＯＤ）观测对急性胃粘膜损伤的保护作用。发现ＳＯＤ抑制应激、结扎幽门和阿斯匹林性胃溃疡的形成，降低大鼠胃溃疡形成过程中胃粘膜丙二醛（ＭＤＡ）含量，保护胃粘膜上皮并促进其粘液的分泌，但对胃酸的分泌量无明显影响。提示：ＳＯＤ的胃粘膜保护作用，可能与提高胃粘膜的防御能力有关。 |
| 关 键 词： | 胃溃疡；超氧化物歧化酶；超氧阴离子；丙二醛 |
The protective effects of superoxide dismutase on acute injury of gastric mucosa |
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| MA Jing,ZHANG Chun Fen,LING Xiu Zhen,WANG Chuan Gong,SI Duan Yun. The protective effects of superoxide dismutase on acute injury of gastric mucosa[J]. Chinese Pharmacological Bulletin, 1996, 12(6): 545-548 | |
| Authors: | MA Jing ZHANG Chun Fen LING Xiu Zhen WANG Chuan Gong SI Duan Yun |
| Abstract: | superoxide dismutase (SOD) dose dependently prevent gastric mucosa from injury induced by stress, pyloric ligation and asprin sepectively in rats. The level of malondialdehyde (MDA) in the mucosa was decreased. The result showed that damaging changes of surface epithelial of the mucosa was descended, and promoted the mucus secret by pretreatment with SOD on pyloric ligation in rats. Its suggested that SOD could protective the cuted injury of gastric mucosa, and it probably increased the preventive ability of gastric mucosal barrier. |
| Keywords: | superoxide dismutase gastric ulcer free radical scavenger malondiadehyde |
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