三氧化二砷对鼻咽癌BALB/c小鼠移植瘤的放射增敏作用

目的通过动物移植瘤模型探讨三氧化二砷对鼻咽癌的放射增敏作用。方法将荷SCNE-1鼻咽癌的BALB／c小鼠随机分为对照组和综合组，对照组给予单纯放射治疗，不给予药物处理，下设空白对照、2、4和6Gy4个不同的放射剂量亚组；综合组所有动物均行药物治疗，下设药物对照组(单纯用药，不照射)、2、4和6Gy4个不同的放射剂量亚组，综合组于肿瘤成活后连续6d经腹腔注射三氧化二砷，药物剂量为4mg/kg鼠重；第7天移植瘤局部给予140kV深部x射线一次性照射。每组(或亚组)各4只小鼠。结果对照组中2、4和6Gy亚组移植瘤体积达到照射前4倍的时间(TCT4)较空白对照组分别延长了1．7、7．8和11．8d；综合组移植瘤TCT4较药物对照组分别延迟了2．2、13．2和24．2d。生长延迟4、8和10d时的肿瘤生长延迟增敏比分别为1．55、1．71和1．77。结论三氧化二砷在BALB／c小鼠体内对鼻咽癌移植瘤有放射增敏作用。

Arsenic trioxide (As2O3) enhances radiosensitivity of nasopharyngeal carcinoma in vivo

Objective To determine whether As 2O 3 could enhance the radiosensitivity of nasopharyngeal carcinoma(NPC)in vivo. Methods BALB/c mice bearing NPC xenografts,CSNET-1,were randomized into control and experimental groups.As 2O 3 at a dosage of 4 mg/kg body weight was administered i.p. for consecutive 6 days to the experimental group.On the 7th day,the BALB/c mice in the experimental group were given 0 Gy,2 Gy,4 Gy and 6 Gy of X-irradiation,respectively.The volumes of the transplanted tumors were then measured twice a week until reaching at least 4 times of the initial volumes.Tumor growth delay and radiosensitizer enhance ratio were calculated. Results In vivo study showed that As 2O\-3 could inhibit the growth of the xenograft tumors.The SER were 1.55,1.71,and 1.77 for the tumor growth delay time of 4,8,12 days,respectively.No severe toxicity was observed in the mice either by biochemical or by histological examination. Conclusion As\-2O\-3 is a potential radiosensitizer for nasopharyngeal carcinoma in vivo.