| STUDIES OF HLA-D REGION DNA POLYMORPHISM IN INSULIN-DEPENDENT DIBETES MELLITUS |
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| 作者姓名： | 谌月新 王亚新 林性玉 冯波 孙婕 冯际平 陈仁彪 陈诗书 万春梅 许曼音 |
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| 作者单位： | Faculty of Basic Medical Sciences，SSMU，Shanghai，Faculty of Basic Medical Sciences，SSMU，Shanghai，Faculty of Basic Medical Sciences，SSMU，Shanghai，Faculty of Basic Medical Sciences，SSMU，Shanghai，Faculty of Basic Medical Sciences，SSMU，Shanghai，Faculty of Basic Medical Sciences，SSMU，Shanghai，Faculty of Basic Medical Sciences，SSMU，Shanghai，Faculty of Basic Medical Sciences，SSMU，Shanghai，Shanghai Institute of Endocrinology，Shanghai，Shanghai Institute of Endocrinology，Shanghai |
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| 摘 要： | Restriction fragment length polymorphisms (RFLPs) of peripheral leucocyte DNA in insulin-dependent diabetes mellitus (IDDM) patients and in controls were studied with Southern blot analysis. IDDM has been reportedly associated positively with the HLA-DR3 and-DR4 in Caucasians, with the HLA-DR3 and-DR9 in Chinese, and negatively with the HLA-DR2 in both Caucasians and Chinese, Using an HLA-DQβcDNA probe, an EcoRI 2.2 kb fragment is found associated with DR2 controls (r = 0.78, P=1×10~(-6)), but not with DR2 IDDM patients, their respective frequencies being significantly different (P=0.02). The authors also report here their new findings that the frequencies of the EcoRI3.0 kb and BamHI3.3 kb fragments are both decreased in the patient group (P=0.0032 and P=0.0018 respectively). This suggested certain kinds of mutation such as partial deletion or others in the IDDM patients might have caused the RFLP pattern change as compared to the normal DNA. RFLPs may provide valuable information in searching for the genetic basis of IDDM.
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STUDIES OF HLA-D REGION DNA POLYMORPHISM IN INSULIN-DEPENDENT DIBETES MELLITUS |
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| Chen Yuexin,Wang Yaxin,Lin Xingyu,Feng Bo Sun Jie,Feng Jiping,Chen Renbiao,Chen Shishu Faculty of Basic Medical Sciences,SSMU,Shanghai Wan Chunmei,Xu Manyin.STUDIES OF HLA-D REGION DNA POLYMORPHISM IN INSULIN-DEPENDENT DIBETES MELLITUS[J].Journal of Shanghai Second Medical University(Foreign Language Edition),1988(2). |
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| Authors: | Chen Yuexin Wang Yaxin Lin Xingyu Feng Bo Sun Jie Feng Jiping Chen Renbiao Chen Shishu Faculty of Basic Medical Sciences SSMU Shanghai Wan Chunmei Xu Manyin |
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| Institution: | Chen Yuexin,Wang Yaxin,Lin Xingyu,Feng Bo Sun Jie,Feng Jiping,Chen Renbiao,Chen Shishu Faculty of Basic Medical Sciences,SSMU,Shanghai Wan Chunmei,Xu Manyin Shanghai Institute of Endocrinology,Shanghai |
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| Abstract: | |
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| Keywords: | restriction fragment length polymorphism insulin-dependent diabetes mellitus HL A-D EcoRI BamHI |
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