原发性高血压患者醛固酮合酶基因多态性与血浆醛固酮水平的关系研究

目的 :探索武汉地区汉族高血压人群醛固酮合酶CYP11B2基因 3 44C/T多态性与血浆醛固酮 (pAldo)水平的相关性。方法 :应用PCR RELP技术对 10 6例武汉地区汉族高血压病人的CYP11B2基因 3 44C/T多态性进行分析 ,应用放射免疫法测定 10 6例武汉地区汉族高血压病人的血浆醛固酮水平。结果 :武汉地区汉族高血压人群CYP11B2基因 3 44C/T多态性以TT和CT为主要基因型 ,C等位基因较少见 ,其频率为 0 2 5。高血压患者血浆醛固酮水平在CYP11B2基因 3 44C/T的 3个不同基因型组中差异有显著性 (P <0 0 1)。结论 :武汉地区高血压人群的血浆醛固酮水平与CYP11B2基因 3 44C/T多态性相关 ,且高醛固酮水平与C等位基因相关。

Relationship of aldosterone synthase gene polymorphism with plasma aldosterone levels of essential hypertension patients

Objective To investigate the relationship between the gene polymorphism of aldosterone synthase (CYP11B2) gene and plasma aldosterone (pAldo) levels in Chinese hypertensive patients. Methods The aldosterone synthase gene polymorphism was studied using PCR-RELP techniques in 106 subjects of Chinese Han hypertension people. The plasma aldosterone (pAldo) was measured by radioimmunoassay (RIA). Results Both TT and CT were major frequent genotypes. Significant differences of plasma aldosterone (pAldo)levers were founded among the TT,TC and CC genotypes in essential hypertension population (P<0.01). Conclusion The plasma aldosterone (pAldo) level was associated with aldosterone synthase gene polymorphism in Chinese Han people with essential hypertension, and the -344C allele was associated with higher plasma aldosterone levels (P<0.05).