| 七氟醚对大鼠疼痛行为的影响及脊髓星形胶质细胞的激活作用 |
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| 引用本文： | 林智平. 七氟醚对大鼠疼痛行为的影响及脊髓星形胶质细胞的激活作用[J]. 医学争鸣, 2009, 0(24): 2944-2946 |
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| 作者姓名： | 林智平 |
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| 作者单位： | 福建省肿瘤医院麻醉科; |
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| 摘 要： | 目的：观察七氟醚对大鼠后爪趾部切口疼痛模型的疼痛行为和脊髓星形胶质细胞激活程度的影响.方法：选取健康成年SD大鼠100只,雌雄各半,建立大鼠疼痛模型,选择造模成功模型80只,随机分为对照组（n=50）和七氟醚处理组（n=40）.分别于术前,术后6h,24h,3d,5d各随机选取10只大鼠,计算累计疼痛评分及机械缩足反射阈值.取L4～6脊髓,观察胶质纤维酸性蛋白（GFAP）变化并进行半定量测定.结果：两组的累计疼痛评分无统计学差异.两组的机械缩足反射阈值在术后先降低后逐渐升高.七氟醚处理组的阈值于术后5d恢复至正常,而对照组的阈值在术后5d仍低于正常.与对照组相比较,七氟醚处理组同侧脊髓背角的GFAP染色虽轻度增强,但未出现明显的峰值.结论：七氟醚则可能通过抑制脊髓星形胶质细胞的激活来减弱术后的机械痛敏.
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| 关 键 词： | 七氟醚 疼痛行为 胶质纤维酸性蛋白 |
Effect of sevoflurane on the pain behaviors and activation of rat spinal cord axtrocytes in a rat model |
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| LIN Zhi-Ping. Effect of sevoflurane on the pain behaviors and activation of rat spinal cord axtrocytes in a rat model[J]. Negative, 2009, 0(24): 2944-2946 |
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| Authors: | LIN Zhi-Ping |
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| Affiliation: | LIN Zhi-Ping Department of Anesthesiology,Fujian Tumor Hospital,Fuzhou 350014,China |
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| Abstract: | AIM:To observe the effects of sevoflurance on pain behaviors and spinal cord astrocytes activation in a rat model of hind paw plantar incision.METHODS:One hundred adult healthy SD rats underwent a unilateral hind paw plantar incision after placidity anaesthesia.Eighty successful modle rats were divided at random into control and experimental groups(n=40).Rats underwent a unilateral hind paw plantar incision after placidity anaesthesia.Ten rats were selected randomly for each time point and were tested befor... |
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| Keywords: | sevoflurance pain behaviors glial fibrillary acidic protein |
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