仙人掌果对高脂血症大鼠血脂及脂质过氧化的影响

目的：探讨仙人掌果原汁及多糖提取物对实验性高脂血症大鼠血脂及脂质过氧化的影响.方法：选80只健康雄性SD大鼠,按血清总胆固醇（TC）水平随机选10只作为空白组,喂饲基础饲料;余70只为高脂造模型组,喂饲高脂饲料3wk,模型建立后,按TC水平随机分成7组（10只/组）：模型组、果原汁低剂量组、果原汁中剂量组、果原汁高剂量组、果原汁多糖低剂量组、果原汁多糖高剂量组、洛伐他汀组,继续喂饲高脂饲料的同时,进行分组分剂量给药.结果：喂饲高脂饲料3wk后,高脂造模型组血清TC,TG,LDL-C水平显著升高（P〈0.01）、HDL-C显著下降（P〈0.05）;给药3wk后,与模型组比较,各给药组TC,TG,LDL-C和apoB水平降低,有统计学差异（P〈0.05或P〈0.01）,果原汁多糖高剂量组、洛伐他汀组HDL-C水平升高,有统计学差异（P〈0.05）,各给药组apoAⅠ水平升高,但无统计学差异;果原汁中剂量组、高剂量组、多糖低剂量组、高剂量组、洛伐他汀组SOD升高,有统计学差异（P〈0.05或P〈0.01）,各给药组MDA降低,有统计学差异（P〈0.05或P〈0.01）.结论：仙人掌果原汁及多糖提取物有明显的降血脂和抗氧化作用，应进一步加强其有效成份和作用机制的研究．

Effects of the cactus pear juice and its polysaccharide extract on the experiment hyperlipemia and lipid peroxidation

AIM:To explore the effect of the cactus pear juice and its polysaccharide extract on the experiment hyperlipemia and lipid peroxidation. METHODS:According to the serum TC level,10 of 80 healthy male SD rat were randomly selected as control group which raised by basic animal feeds.The others were raised by hyper-fatty animal feeds for 3 weeks in order to established the hyperlipemia rat model. Seventy rats were divided into 7 groups randomly according to the serum TC (10/group):model group,low cactus pear ju...