| RGD多肽结合型长循环脂质体的肿瘤靶向性研究 |
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| 引用本文： | 李占山,周瑞华,周冀平,王莉莉. RGD多肽结合型长循环脂质体的肿瘤靶向性研究[J]. 中国药房, 2003, 14(7): 393-394 |
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| 作者姓名： | 李占山 周瑞华 周冀平 王莉莉 |
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| 作者单位： | 1. 华北煤炭医学院附属医院药剂科,唐山市,063000
2. 华北煤炭医学院预防医学系,唐山市,063000 |
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| 摘 要： | 目的 :研究RGD(精氨酸、甘氨酸、天门冬氨酸 )多肽结合型长循环脂质体的肿瘤靶向性。方法 :将长循环脂质体 ,通过共价键反应与RGD基元多肽进行结合 ,然后研究其在荷瘤小白鼠体内的肿瘤靶向性。结果 :RGD结合型长循环脂质体在Colon26荷瘤小白鼠体内具有较好的肿瘤靶向性。结论 :含RGD基元多肽结合型长循环脂质体可能成为一种新型的受体介导靶向制剂
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| 关 键 词： | RGD多肽结合型长循环脂质体 肿瘤靶向性 |
| 文章编号： | 1001-0408(2003)07-0393-02 |
| 修稿时间： | 2002-07-08 |
Study on the Tumor Targeting of RGD-PEG-liposomes |
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| LI Zhanshan,ZHOU Jiping,WANG Lili. Study on the Tumor Targeting of RGD-PEG-liposomes[J]. China Pharmacy, 2003, 14(7): 393-394 |
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| Authors: | LI Zhanshan ZHOU Jiping WANG Lili |
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| Abstract: | OBJECTIVE:To study the tumor targeting of RGD-PEG-liposomes METHODS:RGD-PEG-liposome was prepared by reverse phase evaporation method and combination with GRGDS peptide Tumor targeting was studied in Colon 26 tumor bearing mice RESULTS:RGD-PEG-liposomes showed good tumor targeting effect on colon 26 tumor bearing mice CONCLUSION:RGD containing polypeptide conjugated,long-cyclic lipsome may become a new-type,receptor-mediated targeting agent |
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| Keywords: | RGD-PEG-liposome tumor targeting |
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