| 健骨颗粒对去卵巢骨质疏松模鼠骨代谢的影响 |
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| 引用本文： | 林燕萍,李咏高,马建华,黄美雅.健骨颗粒对去卵巢骨质疏松模鼠骨代谢的影响[J].福建中医学院学报,2001,11(4):17-19. |
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| 作者姓名： | 林燕萍 李咏高 马建华 黄美雅 |
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| 作者单位： | 福建中医学院骨伤系,福建,福州,350003 |
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| 基金项目： | 福建省自然科学基金重大项目 ( C9830 0 0 1) |
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| 摘 要： | 通过对去卵巢骨质疏松模鼠血、尿相关骨代谢生化指标的检测，进一步明确健骨颗粒的药物疗效，并探讨其作用机制。实验结果显示：健骨颗粒能明显减少骨质疏松模鼠骨钙及胶原蛋白的分解代谢，提高血液中镁、雌二醇、降钙素等含量，从而抑制骨吸收，促进骨形成，明显改善骨质疏松模鼠的骨代谢负平衡状况，达到治疗骨质疏松的目的。
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| 关 键 词： | 骨质疏松 动物模型 血尿生化指标 健骨颗粒 中医药疗法 |
| 文章编号： | 1004-5627(2001)04-0017-03 |
| 修稿时间： | 2001年8月25日 |
Effects of JIANGU Granule on Bone Metabolism of Ovariectomized Osteoporosis Rats |
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| LIN Yan ping,LI Yong gao,MA Jian hua,et al\,.Effects of JIANGU Granule on Bone Metabolism of Ovariectomized Osteoporosis Rats[J].Journal of Fujian College of Traditional Chinese Medicine,2001,11(4):17-19. |
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| Authors: | LIN Yan ping LI Yong gao MA Jian hua et al\ |
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| Abstract: | To study the effects of JIANGU granule on osteoporosis and its mechanism,the blood and urine biochemical indexes relating to bone metabolism in ovariectomized osteoporosis rats were tested.The result showed that the granule could obviously decrease the bone mineral and collagen catabolism of osteoporosis rats,significantly increase concentration of Mg,estradiol(E2) and calcitonin in blood,consequently inhibit the bone resorption and accelerate the bone formation along with improve the bone metabolic balance of osteoporosis rats.It indicates JIANGU granule has the therapeutic effects on osteoporosis. |
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| Keywords: | osteoporosis animal models blood and urine biochemical indexes JIANGU granule |
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