|
|||||
|
|
| 新型膦酸酯类似物Mannich碱的合成 | |
| 引用本文： | 刘静姿,胡俊锋,史大斌. 新型膦酸酯类似物Mannich碱的合成[J]. 遵义医学院学报, 2014, 0(2): 173-177 |
| 作者姓名： | 刘静姿 胡俊锋 史大斌 |
| 作者单位： | [1]贵阳医学院,贵州贵阳550004; [2]遵义医学院,贵州遵义563099 |
| 基金项目： | 国家自然科学基金资助项目（NO：81160385）;贵州省科技厅项目（NO：黔科J字[2007]2146,NO：黔科合sY字[2012]3103）;贵州省教育厅资助项目（NO：[黔省专合字2012]89）. |
| 摘 要： | 目的 合成新型膦酸酯类似物Mannich碱以及研究膦酸酯类Mannich反应.方法 在无酸催化条件下,经两次Mannich反应合成膦酸酯类Mannich碱.结果 部分化合物的结构经IR,1HNMR和元素分析等确证,合成了膦酸酯类似物Mannich碱.结论 部分类Mannich碱产物收率较高,副产物较少,同时分析讨论了该类Mannich反应可能的反应机理,对拓宽Mannich反应的应用范围和研究膦酸酯类Mannich反应机理具有一定参考意义. |
| 关 键 词： | Mannich反应 亚膦酸二乙酯 合成 |
The synthesis of novel phosphonate analogue Mannich bases |
|
| Affiliation: | Liu Jingzi, Hu Junfeng, Shi Dabin ( 1. Guiyang Medical University, Guiyang Guizhou 550004, China; 2. Zunyi Medical University, Zunyi Guizhou 563099, China) |
| Abstract: | Objective To synthesize the novel phosphonate analogue Mannich bases and study the Mannich reaction containing phosphonate moiety. Methods The Mannich bases containing phosphonate moiety were synthesized under no catalyst through twice Mannich reaction. Results The structures of compounds were authenticated by IR, 1HNMR and element analysis. Conclusion The Mannich bases are prepared with higher product closes rate and less byproduct, which provides the theoretical basis for enlarging the application scope of Mannich reaction and investigating the mechanisms of Mannich reaction containing phosphonate moiety. |
| Keywords: | mannich reaction diethyl phosphate synthesis |
| 本文献已被 CNKI 维普 等数据库收录！ | |