| 羟氨苄青霉素药物动力学研究 |
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| 引用本文： | 孔晓东,蔡玉珉.羟氨苄青霉素药物动力学研究[J].沈阳药科大学学报,1986(4). |
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| 作者姓名： | 孔晓东 蔡玉珉 |
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| 作者单位： | 沈阳药学院药剂教研室，沈阳药学院药剂教研室 |
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| 摘 要： | 采用铜离子作催化剂,pH5.2磷酸柠檬酸缓冲液中75℃加热40分钟,320nm 处测定吸收度检测尿中羟氨苄青霉素含量,重现性良好,最终测定浓度为2-40μg/ml。初步考查结果表明,丙磺舒延长羟氨苄青霉素体内滞留时间,生物半衰期增加30%,而8小时内尿中回收原型药物占投药量百分率不变。
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| 关 键 词： | 羟氨苄青霉素 分光光度法 丙磺舒 药物动力学 |
STUDIES ON PHARMACOKINETICS OF AMOXICILLIN |
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| Kong Xiaodong Cai Yumin.STUDIES ON PHARMACOKINETICS OF AMOXICILLIN[J].Journal of Shenyang Pharmaceutical University,1986(4). |
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| Authors: | Kong Xiaodong Cai Yumin |
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| Institution: | Kong Xiaodong Cai Yumin Department of Pharmacy |
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| Abstract: | A rapid and convenient method for the determination of amoxicillin(Ⅰ)in urine was based on the spectrophotometric measurement at 320nm of the product of(Ⅰ),formed by heating at 75℃ for 40min,in Cu~(++) solution at pH 5.2.The method,which permits detection of concentration of(Ⅰ)from 2μg/ml to 40μg/ml, is reproducible.Pharmacokinetical analysis of the data of urine drug levels after oral administration of(Ⅰ)with and without probenecid(Ⅱ)indicated that(Ⅱ) could remarkably increase the half-life and mean resident time of(Ⅰ)in man. |
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| Keywords: | Amoxicillin Spectrophotometric method Probenecid Pharmacokinetics |
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