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X综合征患者血浆内皮素-1,降钙素基因相关肽水平变化及其临床意义
引用本文:孙建辉,李雄,徐坚,金建芬,李佩璋. X综合征患者血浆内皮素-1,降钙素基因相关肽水平变化及其临床意义[J]. 中国心血管杂志, 1999, 0(3)
作者姓名:孙建辉  李雄  徐坚  金建芬  李佩璋
作者单位:杭州市第一人民医院心内科 杭州310006(孙建辉,李雄,徐坚,金建芬),杭州市第一人民医院心内科 杭州310006(李佩璋)
摘    要:
目的 探讨X综合征病人血浆内皮素-1(ET-1)和降钙素基因相关肽(CGRP)浓度变化与发病的关系.方法 测定34例X综合征病人ET-1和CGRP的血浆浓度,同时与29例无心肌缺血的对照组作比较分析.结果 ET-1:X综合征组血浆浓度(81.94±10.76ng/L)显著高于对照组(56.71±11.29ng/L,P<0.01).CGRP:X综合征组血浆浓度(50.74±13.26)ng/L显著低于对照组(64.89±11.58ng/L,P<0.01).ET-1/CGRP比值:X综合征组(1.58±0.49)显著高于对照组(0.91±0.33,P<0.01).结论 显著增高的ET-1水平和明显降低的CGRP浓度在X综合征发病中起重要作用.

关 键 词:X综合征  内皮素  降钙素基因相关肽

Levels of Plasma Endothelin, Calcitonin Gene-related Peptide and Their Clinical Significance in patients With Syndrome X
SUNJianhui,LI Xiong,XU Jian,JIN Jianfen,LI Peizhang. Levels of Plasma Endothelin, Calcitonin Gene-related Peptide and Their Clinical Significance in patients With Syndrome X[J]. Chinese Journal of Cardiovascular Medicine, 1999, 0(3)
Authors:SUNJianhui  LI Xiong  XU Jian  JIN Jianfen  LI Peizhang
Affiliation:SUNJianhui,LI Xiong,XU Jian,JIN Jianfen,LI Peizhang. Department of Cardiology,Hangzhou first people's Hospital
Abstract:
Object To study the relation between the levels of ET-1 ,CGRP and syndrome X. Mothods Levels of ET-1 ,CGRP were measured in 34 patients with syndrome X and in 29 normal control subjects. Results In the syndrome X group,the levels of plasma ET-1 were higher than those of the normal control (P<0. 01) ,the levels of plasma CGRP were lower than the normal con-trol(P<0. 01) ,the ratio of ET-1/CGRP were higher than the normal control(P<0. 01). Conclusion The increase of plasma ET-1 and decrease of CGRP could play an active role in the disease process.
Keywords:Syndrome  X  Endothelin  Calcitonin gene-related peptide
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