Successful autologous peripheral blood stem cell collection using large volume leukapheresis in patients with very low or undetectable peripheral blood CD34+ progenitor cells |
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| Affiliation: | 1. Cardiovascular Institute Dedinje, Milana Tepića 1, 11000, Belgrade, Serbia;2. Gulf Coasts Biologics Inc, 4331 Veronica S Shoemaker Blvd, Fort Myers, FL, 33916, United States;3. Clinical Centre of Serbia, Pasterova2, 11000, Belgrade, Serbia;4. St Catherine’s Hospital, Michelangelolaan 2, 5623 EJ, Eindhoven, the Netherlands;5. Emergency Medical Centre of Montenegro, Vaka Đurovića bb, 81110, Podgorica, Montenegro;1. Department of Haematology, Haemophilia Care Centre, Rouen University Hospital, France;2. Department of Haematology, Le Havre Hospital, France;3. Department of Pharmacology, Rouen University Hospital, France;4. Department of Paediatrics, Clinical and Molecular Haemostasis, Frankfurt University Hospital, Frankfurt am Main, Germany;1. Department of Hematology and Transfusion Medicine, Carlo Poma Hospital, Mantua, Italy;2. North-Western Tuscany Blood Bank, Pisa University Hospital, Pisa, Italy;1. Division of Transfusion, Okayama University Hospital, Okayama, Japan;2. Department of Hematology and Oncology, Okayama University Hospital, Okayama, Japan;3. Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan;4. Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan |
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| Abstract: | Autologous stem cell transplantation provides some patients with hematolymphoid and solid organ malignancies an opportunity for cure. Management of peripheral hematopoietic stem cell (HSC) collections differs among institutions, especially if a very low pre-procedure peripheral blood CD34+ cell count (PBCD34) is demonstrated. This study retrospectively analyzed results of large-volume peripheral HSC collections in 91 patients over approximately two years. Fifteen patients with PBCD34 < 10 × 10e6/l (eleven with undetectable PBCD34) were compared to 76 patients with higher counts on the first collection day (adequate mobilizers). The poor mobilizer group had significantly lower pre-collection WBC and platelet counts as well as collection yields. However, most patients with PBCD34 < 10 × 10e6/l (80 %) collected the minimum target for HSC transplant (2.0 × 10e6 CD34+ cells/kg) in <5 consecutive days of collection, and those who did collect the minimum successfully underwent autologous transplantation, with hematopoietic engraftment and long-term survival comparable to the adequate mobilizers. Successful HSC collection may often be achieved regardless of d 1 PBCD34 counts. |
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| Keywords: | Poor mobilizer Apheresis G-CSF Plerixafor |
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