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Restoring neuronal chloride homeostasis with anti-NKCC1 gene therapy rescues cognitive deficits in a mouse model of Down syndrome
Institution:1. Brain Development and Disease Laboratory, Istituto Italiano di Tecnologia, 16163 Genoa, Italy;2. Center for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, 16132 Genoa, Italy;3. IRCSS Ospedale Policlinico San Martino, 16132 Genoa, Italy;4. Animal Facility, Istituto Italiano di Tecnologia, 16163 Genoa, Italy;5. Genethon, 91000 Evry, France;6. Paris-Saclay University, University Evry, Inserm, Integrare research unit UMR_S951, 91000 Evry, France;7. Dulbecco Telethon Institute, 00185 Rome, Italy
Abstract:
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  • Keywords:Down syndrome  GABA  cognitive disabilities  gene therapy  RNA interference  chloride  inhibition  AAV  learning and memory
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