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| c-myc、hTERT在4-氨基-2-三氟甲基苯基维甲酸酯诱导NB4细胞分化中的作用 | |
| 引用本文： | 陈慧慧,陈飞虎,徐佼,洪凡青,王新群,石静波,吴繁荣. c-myc、hTERT在4-氨基-2-三氟甲基苯基维甲酸酯诱导NB4细胞分化中的作用[J]. 安徽医科大学学报, 2011, 46(3): 235-240 |
| 作者姓名： | 陈慧慧 陈飞虎 徐佼 洪凡青 王新群 石静波 吴繁荣 |
| 作者单位： | 安徽医科大学药学院,合肥,230032;安徽医科大学药学院,合肥,230032;安徽医科大学药学院,合肥,230032;安徽医科大学药学院,合肥,230032;安徽医科大学药学院,合肥,230032;安徽医科大学药学院,合肥,230032;安徽医科大学药学院,合肥,230032 |
| 摘 要： | 目的 探讨c-myc、hTERT在4-氨基-2-三氟甲基苯基维甲酸酯(ATPR)诱导NB4细胞分化中的作用.方法 NB4细胞按不同处理方式分为以下各组:以RPMI 1640培养基作空白对照,乙醇作溶剂对照,全反式维甲酸(ATRA,1 μmol/L)作阳性对照,ATPR(1 μmol/L)处理组.采用RT-PCR法和We... |
| 关 键 词： | 白血病 基因 myc 端粒 末端转移酶 |
Effects of c-myc,hTERT on differentiation of NB4 cells induced by 4-amino-2-trifluoromethyl-phenyl retinate |
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| Chen Huihui,Chen Feihu,Xu Jiao,et al. Effects of c-myc,hTERT on differentiation of NB4 cells induced by 4-amino-2-trifluoromethyl-phenyl retinate[J]. Acta Universitis Medicinalis Anhui, 2011, 46(3): 235-240 | |
| Authors: | Chen Huihui Chen Feihu Xu Jiao et al |
| Affiliation: | Chen Huihui,Chen Feihu,Xu Jiao,et al(School of Pharmacy,Anhui Medical University,Hefei 230032) |
| Abstract: | Objective To explore the effects of c-myc,hTERT on differentiation of NB4 cells induced by 4-amino-2-trifluoromethyl-phenyl retinate(ATPR).Methods The mRNA and protein expressions of c-myc,hTERT were detected by RT-PCR and Western blot with differentiation of NB4 cells induced by ATPR for 4 days and further to conduct the analysis of the time-effects.Results The mRNA and protein expressions of c-myc,hTERT were significantly decreased after treatment with ATPR on NB4 cells for 4 days,and the change of expres... |
| Keywords: | leukemia genes myc telomerase |
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