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| 三氟柳的合成工艺研究 | |
| 引用本文： | 吕晓燕,周亚球,徐奎,冉帆,徐济恒. 三氟柳的合成工艺研究[J]. 安徽医药, 2011, 15(5): 553-555 |
| 作者姓名： | 吕晓燕 周亚球 徐奎 冉帆 徐济恒 |
| 作者单位： | 安徽中医学院,安徽,合肥,230031;安徽中医学院,安徽,合肥,230031;安徽中医学院,安徽,合肥,230031;安徽中医学院,安徽,合肥,230031;安徽中医学院,安徽,合肥,230031 |
| 摘 要： | 目的 三氟柳合成工艺的优选.方法 通过试验考察不同酰化试剂、催化剂、反应温度、反应时间对合成工艺的影响.结果 以乙酸酐为酰化试剂和多聚磷酸为催化剂在50℃下反应30 min制得了高产率且高纯度的三氟柳.结论 该工艺简单,易于控制,产率高,为89.5%. |
| 关 键 词： | 三氟柳 4-三氟甲基水杨酸 乙酸酐 多聚磷酸 |
Technology research of triflusal synthesis |
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| LU Xiao-yan,ZHOU Ya-qiu,XU Kui,RAN Fan,XU Ji-heng. Technology research of triflusal synthesis[J]. Anhui Medical and Pharmaceutical Journal, 2011, 15(5): 553-555 | |
| Authors: | LU Xiao-yan ZHOU Ya-qiu XU Kui RAN Fan XU Ji-heng |
| Affiliation: | Lü Xiao-yan,ZHOU Ya-qiu,XU Kui,RAN Fan,XU Ji-heng(Anhui College of Traditional Chinese Medicine,Hefei 230031) |
| Abstract: | Aim To optimize the synthesis of triflusal.Methods Experiments were performed to inspect the different acylation reagent,catalyst,reaction temperature,reaction time which influenced the synthesis.Results By using acetic anhydride as acylating agent,polyphosphoric acid as catalyst at 50 ℃ for 30 minutes,we got high yields and high purity of triflusal.Conclusion This synthesis is simple and easy to control.The rate is high that is,89.5%. |
| Keywords: | triflusal 4-trifluoromethyl salicylic acid acetic anhydride polyphosphoric acid |
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