| 阿司匹林联合氟西汀对CUMS抑郁模型大鼠行为学及海马PKA表达的影响 |
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| 引用本文： | 周冉,徐维平,王伟迪,魏伟.阿司匹林联合氟西汀对CUMS抑郁模型大鼠行为学及海马PKA表达的影响[J].安徽医科大学学报,2011,46(1):40-43. |
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| 作者姓名： | 周冉 徐维平 王伟迪 魏伟 |
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| 作者单位： | 安徽医科大学临床药理研究所,抗炎免疫药理学省部共建教育部重点实验室,抗炎免疫药物安徽省工程技术研究中心,合肥,230032;安徽医科大学临床药理研究所,抗炎免疫药理学省部共建教育部重点实验室,抗炎免疫药物安徽省工程技术研究中心,合肥,230032;安徽医科大学附属省立医院药剂科,合肥,230001 |
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| 基金项目： | 安徽省2008年人才开发专项基金 |
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| 摘 要： | 目的 通过观察阿司匹林联合氟西汀对慢性轻度不可预见性应激(CUMS)大鼠行为学及海马蛋白激酶A(PKA)表达的影响,探讨阿司匹林联合氟西汀的抗抑郁效果.方法 56只SD大鼠,随机分为7组:正常组(A组)、模型组(B组)、大剂量氟西汀联合阿司匹林用药组(C组)、大剂量氟西汀组(D组)、小剂量氟西汀联合阿司匹林用药组(E组...
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| 关 键 词： | 抑郁症/药物疗法 阿司匹林/治疗应用 氟西汀/治疗应用 环AMP依赖性蛋白激酶类 |
Effects of aspirin and fluoxetine on the behaviors and hippocampal and cortical expressions of PKA in rats with chronic unpredictable mild stress-induced depression |
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| Zhou Ran,Xu Weiping,Wang Weidi,et al.Effects of aspirin and fluoxetine on the behaviors and hippocampal and cortical expressions of PKA in rats with chronic unpredictable mild stress-induced depression[J].Acta Universitis Medicinalis Anhui,2011,46(1):40-43. |
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| Authors: | Zhou Ran Xu Weiping Wang Weidi |
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| Institution: | Zhou Ran1,Xu Weiping1,2,Wang Weidi1,et al(1Institute of Clinical Pharmacology,Anhui Medical University,Hefei 230032,2Dept of Pharmacy,The Affiliated Provincial Hospital of Anhui Medical University,Hefei 230001) |
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| Abstract: | Objective To explore the anti-depressive effect of aspirin and fluoxetine by observing the behaviors and expressions of PKA in the hippocampus of rats with chronic unpredictable mild stress-induced depression.Methods Fifty-six SD rats were devided into seven groups:normal control(group A),depression model(group B),large-dose of fluoxetine and aspirin group(group C),large-dose of fluoxetine group(group D),low-dose of fluoxetine and aspirin group(group E),low-dose of fluoxetine group(group F),aspirin group(gr... |
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| Keywords: | depressive disorder/drug therapy aspirin/therapeutic use fluoxetine/therapeutic use cyclic AMP-dependent protein kinases |
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