多发性骨髓瘤患者血清血管生成素水平的测定及意义

目的研究血管生成素（Angs）与多发性骨髓瘤（MM）的关系并探讨其临床意义。方法用双抗体夹心酶联免疫吸附测定法检测60例MM患者不同时期的Angs血清浓度，观察其与MM临床分期、肿瘤量分级和治疗效果的关系。结果MM患者血清中Ang-2较正常对照组明显升高；血清Ang-1含量与正常对照组差异无统计学意义。MM患者Ⅱ期的Ang-2血清水平显著低于Ⅲ期。不同肿瘤量分级的MM患者血清Ang-2含量差异有统计学意义。MM治疗有效者，血清Ang-2水平比治疗前明显降低，血清Ang-1水平与治疗前差异无统计学意义；治疗无效者，其血清Ang-1、Ang-2含量与治疗前比较差异均无统计学意义。结论MM患者血清Ang-2水平测定对MM的发病机制研究、病情评价、疗效监测、预后预测有一定意义。

Detection and Clinical Implications of Serum Angiopoietins in Multiple Myeloma Patients

ObjectiveTo explore the relationship of angiopoietins (Angs) with multiple myeloma(MM) and its clinical significance.MethodsThe serum concentration of Angs in different periods was detected by double-antibody sandwich enzyme-linked immunosorbent assays technique in 60 cases of MM patients and 20 controls.The associations between the serum cytokines levels with MM stages( Ⅱ～ Ⅲ), tumor load and the curative effect were observed,respectively.ResultsPretreatment MM had significantly higher serum Ang-2 levels than controls.Serum Ang-1 levels in pretreatment MM had no significant difference compared with controls.Pretreatment serum Ang -2 levels were significantly lower in stage Ⅱ than in stage Ⅲ of MM.There weas significant difference between the different tumor load.In the patients responding to chemotherapy,Ang-2 serum levels was significantly decreased, while serum Ang-1 levels was no significant difference. In the patients who did not achieve a remission, there was no significantly change in serum Ang-1 levels and serum Ang-2 levels.ConclusionSerum levels of Ang-2 detection in MM patients is a certain extent significance to study of the pathogenesis of MM, the condition evaluation, efficacy monitoring, and outcome of prediction.