Endoplasmic reticulum stress and apoptosis via PERK-eIF2α-CHOP signaling in the methamphetamine-induced chronic pulmonary injury |
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| Institution: | 1. Department of Immunology and Pathogenic Biology, Xi''an Jiaotong University School of Basic Medical Sciences, Xi''an 710061, China;2. Department of Laboratory, The Second Affiliated Hospital of Medical College of Xi''an Jiaotong University, Xi''an 71004, China;3. Department of Cardiovascular Surgery, The First Affiliated Hospital of Medical College of Xi''an Jiaotong University, Xi''an 710061, China;4. Pathology Department, The Second Affiliated Hospital of Medical College of Xi''an Jiaotong University, Xi''an 710004, China;5. VIP Internal Medicine Department, Lanzhou University Second Hospital, Lanzhou 730030, China;6. Graduate Teaching and Experiment Centre, Xi''an Jiaotong University School of Basic Medical Sciences, Xi''an 710061, China;7. Forensic Medicine College of Xi''an Jiaotong University, Key Laboratory of the Health Ministry for Forensic Medicine, Key Laboratory of the Ministry of Education for Environment and Genes Related to Diseases, Xi''an 710061, China;1. Division of Gynecologic Oncology, Department of Obstetrics/Gynecology, University of Southern California, Los Angeles, CA, United States;2. Biostatistics Shared Resource, USC Norris Comprehensive Cancer Center, and Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States;3. Women''s Cancer Program, USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, United States;4. Department of Pathology and Gynecologic Oncology, University of Southern California, Los Angeles, CA, United States |
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| Abstract: | Methamphetamine (MA) leads to multiple organs lesions and apoptosis. The aim of this study is to investigate if endoplasmic reticulum stress (ERS) – initiated apoptosis is involved in the chronic pulmonary injury induced by MA. In this study, rats were divided into a control group, methamphetamine 5 mg/kg group and methamphetamine 10 mg/kg group. This study found that the protein level of GRP78 is higher in M10 group than in control group. PERK signaling and the relevant apoptosis factors were also activated. Morphological measurements showed that protein BAX and CHOP accumulated in the alveolar epithelium and the alveolar walls with epithelium were damaged and that the number of pulmonary alveoli decreased. The findings showed that ERS and PERK pathway are activated and eventually lead to apoptosis. Severe ERS mediated the apoptosis of alveolar epithelium cells as well as decreasing numbers of pulmonary alveoli. |
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| Keywords: | Endoplasmic reticulum stress Apoptosis PERK/eIF2α CHOP Methamphetamine Chronic pulmonary injury |
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