Cognitive impairment is associated with Hoehn and Yahr stages in early,de novo Parkinson disease patients |
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| Affiliation: | 1. Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, MRI Research Center SUN-FISM, University of Campania “Luigi Vanvitelli”, Piazza Miraglia 2, 80138, Naples, Italy;2. Department of Psychology, University of Campania “Luigi Vanvitelli”, Viale Ellittico 31, 81100, Caserta, Italy;3. ICS Maugeri, Scientific Institute of Telese, Via Bagni Vecchi 2, 82037, Telese, Italy;4. IDC-Hermitage-Capodimonte, Via Cupa Delle Tozzole 2, 80131, Naples, Italy;1. Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA;2. Mayo Clinic School of Medicine, Mayo Clinic, Rochester, MN 55905, USA;1. Department of Neurology, University of California, San Francisco, CA, USA;2. Virginia Tech Carilion School of Medicine, Roanoke, VA, USA;3. Department of Neurosurgery, University of California, San Francisco, CA, USA;1. National Parkinson Foundation International Centre of Excellence, King''s College London, London, UK;2. National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre and Dementia Unit at South London and Maudsley NHS Foundation Trust and King''s College London, UK;3. Department of Clinical Neuroscience, Institute of Psychiatry, Kings College London, London, UK;4. Department of Statistics, Centre of Human and Social Sciences, Spanish Council for Scientific Research, Madrid, Spain;5. Movement Disorders Program, Medical College of Georgia, Augusta, GA, USA;6. UCL Institute of Neurology, Department of Clinical Neurosciences London, London, UK;7. Department of Psychology, Institute of Psychiatry, Kings College London, London, UK;8. Department for Parkinson''s Disease, IRCCS San Camillo, Venice, Italy;9. Department of Neurology, IRCCS San Raffaele, Rome, Italy;10. University of Lund, Lund, Sweden;11. Bangur Institute of Neurology, Kolkata, India;12. Department of Neurology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan;13. Department of Community Health Medicine, Hyogo College of Medicine Division of Neurology, Hyogo College of Medicine Hospital, Japan;14. National Centre of Epidemiology and Centre for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Carlos III Institute of Health, Madrid, Spain |
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| Abstract: | ![]()
IntroductionThe relationship between motor impairment and cognitive deterioration has long been described in Parkinson's disease (PD). The aim of the study was to compare cognitive performance of de novo PD patients in relation to the motor impairment severity according to Hoehn and Yahr (HY) stages.MethodsForty de novo PD patients at HY stage I and 40 patients at HY stage II completed a standardized neuropsychological battery. A multivariate analysis of covariance was used to compare cognitive performance between HY groups. Odds ratios (ORs) were employed to explore the risk of cognitive impairment between HY stages. Finally, the prevalence of mild cognitive impairment (MCI) was estimated for patients in HY stage I and II.ResultsPatients at HY stage I obtained better scores on neuropsychological tests than patients at HY stage II (p = 0.001). Univariate analysis of covariance revealed significant differences between HY stages on Rey's auditory verbal learning test -immediate recall (p < 0.0001), 10 points Clock Drawing Test (p = 0.002), and Rey-Osterrieth Complex Figure Test -copy (p < 0.0001). ORs of having cognitive impairment were greater for HY stage II than stage I group. MCI occurred in 7.5% of patients in HY stage I, and in 42.5% of patients in HY stage II.ConclusionIn de novo PD patients, the severity of motor impairment at the diagnosis is associated to cognitive deficits and higher risk of MCI. |
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| Keywords: | Cognition Hoehn and Yahr Parkinson's disease Mild cognitive impairment PD |
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