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| 模拟高原低氧环境暴露下家兔小肠黏膜扫描电镜观察 | |
| 引用本文： | 周波,杨定周,周其全.模拟高原低氧环境暴露下家兔小肠黏膜扫描电镜观察[J].胃肠病学和肝病学杂志,2009,18(8):751-753. |
| 作者姓名： | 周波 杨定周 周其全 |
| 作者单位： | 1. 解放军第25医院检验科,甘肃,酒泉,735000 2. 西藏军区总医院全军高山病防治研究中心 3. 第三军医大学高原军事医学系高原疾病学教研室 |
| 摘 要： | 目的探讨高原低氧环境暴露对肠黏膜的损伤作用及对急性高原病发生发展的影响。方法将健康家兔暴露于海拔5000m的模拟高原低氧环境下3天，取小肠黏膜标本扫描电镜观察。结果高原环境暴露下家兔小肠黏膜表面粗糙不平，绒毛卷曲倒伏凝结呈板块状，表面可见较多的缺损，缺损处可见大量纤维细丝及漏出的双凹碟形红细胞。结论高原低氧暴露能引起严重的肠黏膜结构破坏，使黏膜屏障功能减弱， |
| 关 键 词： | 高原环境 肠黏膜 超微结构 低氧损伤 |
The SEM observation of small intestinal mucosa in the rabbits under simulated high-altitude hypoxia |
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| ZHOU Bo,YANG Dingzhou,ZHOU Qiquan.The SEM observation of small intestinal mucosa in the rabbits under simulated high-altitude hypoxia[J].Chinese Journal of Gastroenterology and Hepatology,2009,18(8):751-753. | |
| Authors: | ZHOU Bo YANG Dingzhou ZHOU Qiquan |
| Institution: | ZHOU Bo, YANG Dingzhou, ZHOU Qiquan(1. Department of Medical Laboratory, the 25 Hospital of PLA, Jiuquan 735000 ; 2. Research Center of Mountain Sickness, General Hospital of Tibetan Military Area; 3. Department of High Altitude Disease, High Altitude Military Medicine College, the Third Military Medical University, China) |
| Abstract: | Objective To explore the direct morphologic evidences of intestinal mucosa under simulated high-altitude hypoxia in rabbits. Methods Sixteen male rabbits were divided into 2 groups： the normoxia group and hypoxia group （simulating the altitude 5 000 meters, 3 days）. Their small intestinal mueosa were observed by scanning electron microscope （SEM）. Results The small intestinal mucosa surface of hypoxia group was rough, the microvilli curled to a streaky structure with many defects. In the defects, there were many fabric filament and bicon-dished red cells. Conclusion High-altitude hypoxia can make intestinal mucosa disorganization and reduce the mucosal barrier function. |
| Keywords: | High-altitude Intestinal mucosa Uhrastructure Hypoxic injure |
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