| 非核苷类抗乙型肝炎病毒药物的研究进展 |
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| 引用本文： | 夏广强,赵国明,郑志兵.非核苷类抗乙型肝炎病毒药物的研究进展[J].国外医学(药学分册),2007,34(3):161-164. |
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| 作者姓名： | 夏广强 赵国明 郑志兵 |
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| 作者单位： | 军事医学科学院毒物药物研究所,北京100850 |
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| 基金项目： | 国家重点基础研究发展计划（973计划）资助项目（2004CB518908） |
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| 摘 要： | 目前美国FDA批准的抗乙型肝炎病毒（HBV）药物分为两类：免疫调节剂和核苷类似物。但免疫调节剂的副作用和核苷类似物耐药性病毒株的出现使得慢性乙型肝炎的临床治疗仍然面临着巨大的挑战。因而，非核苷类抗HBV药物的研究引起广泛关注。本文按照不同的结构和作用机制对此类药物的研究进展做一综述。
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| 关 键 词： | 乙型肝炎病毒 抗乙型肝炎病毒药物 非核苷类 |
| 文章编号： | 1001-0971（2007）03-0161-04 |
| 修稿时间： | 2006-11-16 |
Advances in the research on non-nucleos(t)ide chemicals as anti-HBV agents |
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| XIA Guang-qiang, ZHAO Guo-ming, ZHENG Zhi-bing.Advances in the research on non-nucleos(t)ide chemicals as anti-HBV agents[J].Foreign Medical Sciences(Section of Pharmarcy),2007,34(3):161-164. |
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| Authors: | XIA Guang-qiang ZHAO Guo-ming ZHENG Zhi-bing |
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| Institution: | Institute of Phormacology and Toxicology, Academy of Military Medical Sciences, Beifing 100850, China |
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| Abstract: | Current FDA approved drugs for hepatitis B virus(HBV) infection are nucleos(t)ide analogs and immune modulators.However,the use of immune modulators has many side effects while that of nucleos(t)ide analogs can lead to the emergence of resistant viruses.Hence,treatment of chronic hepatitis B remains a clinical challenge.So,new classes of chemicals with novel stuctures and actions against HBV replication arouses much attention.This article summarizes recent research progress of these non-nucleos(t)ide anti-HBV chemicals according to their strcutures and actions. |
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| Keywords: | hepatitis B virus anti-HBV agents non-nucleos(t)ide chemicals |
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