106例抗菌药物致药物不良反应报告分析

目的了解我院抗菌药物致药物不良反应（ADR）发生的特点和规律,为安全用药提供参考,促进临床合理用药。方法对我院2010年7月~2011年6月收集的106例抗菌药物致ADR报告进行回顾性分析评价。结果 106例抗菌药物致ADR报告中,中老年人所占比例最大（64.15%）,以静脉给药为主要给药途径（82.08%）,以皮肤及其附件损害为主要临床表现（39.63%）,涉及药品以喹诺酮类为主,其次是头孢菌素类。结论加强抗菌药物ADR监测,定期分析报告数据,及时为临床提供药品安全信息,减少ADR的发生。

Analysis of 106 cases of antibiotics-induced adverse drug reaction

Objective To investigate the characteristics and regularity of antibiotics-induced adverse drug reaction(ADR) in our hospital,in order to provide reference for security use of drugs,and promote rational drugs use in clinic.Methods 106 cases of antibiotics-induced ADR reports in our hospital from July 2010 to June 2011 were analyzed retrospectively.Results Among 106 ADR reports,the middleaged and elderly patients occupied the largest proportion(64.15%),the main route of administration was intravenous administration(82.08%),and the commonest clinical manifestation was lesion of skin and its appendages(39.63%).Most of ADR cases were induced by quinolones and cephalosporins.Conclusion Great importance should be attached to ADR monitoring and reporting,and regular data analysis.Drug safety information should be provided timely so as to reduce the occurrence of ADR.