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趋化因子及其受体与原发性肝癌的研究进展
引用本文:黎巧连. 趋化因子及其受体与原发性肝癌的研究进展[J]. 医学综述, 2012, 18(8): 1149-1152
作者姓名:黎巧连
作者单位:福建医科大学协和临床医学院,福州,350000;福建省肿瘤医院内科研究室,福州,350000;福建省肿瘤转化医学重点实验室,福州,350014
摘    要:
近年来趋化因子及其受体领域已经受到广泛关注。它们属于细胞因子超家族中的一种,具有众多成员。趋化因子与特异性受体相互结合,在多种生理和病理过程中发挥着重要作用。越来越多的相关研究表明,它们与肿瘤的血管生成、生长、扩散、转移和治疗都有着密切的关系。现就趋化因子及其受体在肝癌发生、发展过程中的关系以及在临床治疗上的价值进行综述。

关 键 词:原发性肝癌  趋化因子  趋化因子受体

Research Progress of Chemokine and Its Receptors and Primary Liver Cancer
LI Qiao-lian. Research Progress of Chemokine and Its Receptors and Primary Liver Cancer[J]. Medical Recapitulate, 2012, 18(8): 1149-1152
Authors:LI Qiao-lian
Affiliation:1,2,3.(1.Union Clinical College of Fujian Medical University,Fuzhou 350000,China;2.Internal Oncology Laboratory of Fujian Provincial Cancer Hospital,Fuzhou 350000,China;3.Fujian Provincial Key Laboratory of Translational Medicine Oncology,Fuzhou 350014,China)
Abstract:
In recent years,the area of chemokines and its receptors has aroused wide concern.They belong to the super family of cell factors with many members.Chemokines play an important role in a variety of physiological and pathological process via binding with the specific receptors.More and more studies show that they have a close relationship with the angiogenesis,growth,diffusion,metastasis and treatment of the tumor.Here is to make a review on the correlation between chemokine and its receptors in the genesis and development of liver cancer and their value in the clinical treatment.
Keywords:Primary liver cancer  Chemokine  Chemokine receptor
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