| 羟基喜树碱预防硬膜外粘连的有效性和安全性研究 |
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| 引用本文： | 孙钰,冯新民,颜连启,蒋百川,虞堂云,王强,戴善和.羟基喜树碱预防硬膜外粘连的有效性和安全性研究[J].临床骨科杂志,2010,13(2):214-217. |
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| 作者姓名： | 孙钰 冯新民 颜连启 蒋百川 虞堂云 王强 戴善和 |
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| 作者单位： | 江苏省苏北人民医院骨科,江苏,扬州,225001 |
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| 摘 要： | 目的探讨局部应用羟基喜树碱(HCPT)预防椎板切除术后硬膜外粘连的效果,并进行安全性评价。方法48只SD大鼠随机分为4组,行L1全椎板切除术后,实验组局部应用不同浓度的HCPT0.1 g/L(A组),0.05 g/L(B组),0.01 g/L(C组)],对照组(D组)应用生理盐水,测定用药前后的体感诱发电位(SEP),并行后肢运动功能评分(BBB评分)。术后4周行肉眼观察、组织学观察、硬膜外瘢痕面积测定及成纤维细胞计数。结果A组无明显硬膜外粘连,瘢痕组织面积及成纤维细胞计数均低于D组(P<0.01),而D组出现致密的硬膜外粘连。所有实验动物无明显中毒症状,用药前后的SEP及BBB后肢运动功能评分差异无统计学意义(P>0.05)。结论局部短时应用浓度为0.1 g/L的HCPT可有效预防硬膜外粘连,且未见明显的毒副作用。
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| 关 键 词： | 羟基喜树碱 硬膜外粘连 椎板切除术 安全性 |
The study of the effect and safety of hydroxycamptothecin in preventing epidural adhesion |
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| SUN Yu,FENG Xin-min,YAN Lian-qi,JIANG Bai-chuan,YU Tang-yun,WANG qiang,DAI Shan-he.The study of the effect and safety of hydroxycamptothecin in preventing epidural adhesion[J].Journal of Clinical Orthopaedics,2010,13(2):214-217. |
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| Authors: | SUN Yu FENG Xin-min YAN Lian-qi JIANG Bai-chuan YU Tang-yun WANG qiang DAI Shan-he |
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| Institution: | SUN Yu,FENG Xin-min,YAN Lian-qi,JIANG Bai-chuan,YU Tang-yun,WANG qiang,DAI Shan-he |
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| Abstract: | Objective To investigate the effectiveness and safety of Hydroxycamptothecin(HCPT) in preventing epidural adhesion after laminectomy.Methods Forty-eight rats were treated with HCPT 0.1 g/L(Group A),0.05 g/L(Group B),0.01 g/L(Group C)],and control Group with saline(Group D) after laminectomies,which were evaluated by macroscopic observation,histological evaluation,the epidural scar area and the fibroblast number after four weeks.SEP and BBB scoring were detected before and after laminectomy.Results No signi... |
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| Keywords: | laminectomy epidural adhesion hydroxycamptothecin safety |
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