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Clinical significance of occult hepatitis B virus infection |
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| Authors: | Romero Miriam Madejón Antonio Fernández-Rodríguez Conrado García-Samaniego Javier |
| Affiliation: | Miriam Romero, Antonio Madejón, Javier García-Samaniego, Hepatology Unit, Hospital Carlos III, CIBERehd, 28029 Madrid, Spain;Conrado Fernández-Rodríguez, Service of Gastroenterology, Hospital Universitario Fundación Alcorcón, Av Budapest-1, 28922 Alcorcón, Madrid, Spain |
| Abstract: | Occult hepatitis B virus(HBV) infection(OBI) is defined as the presence of HBV DNA in the liver(with or without detectable HBV DNA in serum) for individuals testing HBV surface antigen negative.Until recently,the clinical effect of OBI was unclear on the progression of liver disease;on the development of hepatocellular carcinoma;and on the risk for reactivation or transmission of HBV infection.Several studies suggest a high prevalence of OBI among patients with cryptogenic chronic liver disease,but its role... |
| Keywords: | Occult hepatitis B virus infection Liver dis-ease Cryptogenic cirrosis Hepatitis B virus coinfection Human immunodeficiency virus |
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