| 急性冠脉综合征患者血清氮末端脑钠尿肽原水平与冠脉病变程度的关系 |
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| 引用本文： | 王爱萍,张焕轶,杨曙光,吴云,王咏梅,张代民.急性冠脉综合征患者血清氮末端脑钠尿肽原水平与冠脉病变程度的关系[J].心脏杂志,2011,23(5):629-632. |
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| 作者姓名： | 王爱萍 张焕轶 杨曙光 吴云 王咏梅 张代民 |
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| 作者单位： | 1.泰安市中心医院心内科，山东 泰安 271000；2.解放军第88医院心内科，山东 泰安 271000 |
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| 摘 要： | 目的:探讨急性冠脉综合征（ACS）患者血清氮末端脑钠尿肽原（NT-proBNP）水平与冠脉病变程度之间的关系。方法: 对150例因胸痛入院的患者行选择性冠状动脉造影，其中ACS组78例，稳定型心绞痛(SAP)组33例，冠状动脉造影正常组39例，采用冠状动脉造影Gensini积分评价冠状动脉病变的严重程度，同期测定患者血清NT-proBNP及左室射血分数（LVEF），分析NT-proBNP基线水平与LVEF及Gensini积分的关系。结果: ①ACS组NT-proBNP浓度明显高于SAP组与正常组（均P<0.05）。SAP组NT-proBNP浓度明显高于正常组（P<0.05）。②ACS患者NT-proBNP水平与Gensini积分呈正相关（Pearson偏相关系数r＝0.84，P<0.01）。③多元逐步回归结果显示，ACS患者，影响NT-proBNP浓度的因素为冠状动脉造影积分和LVEF（冠状动脉造影Gensini积分的偏决定系数R2=0.8327，P<0.01；LVEF 的偏决定系数R2=0.0034，P>0.05）。结论: ACS患者血清NT-proBNP水平与冠脉病变程度高度相关。
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| 关 键 词： | 急性冠脉综合征 氮末端脑钠尿肽原 左室射血分数 冠状动脉造影 冠脉病变 |
| 收稿时间： | 2011-01-12 |
Association between serum NT-proBNP levels and severity of coronary artery lesions in patients with acute coronary syndromes |
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| WANG Ai-ping,ZHANG Huan-yi,YANG Shu-guang,WU Yun,WANG Yong-mei,ZHANG Dai-min.Association between serum NT-proBNP levels and severity of coronary artery lesions in patients with acute coronary syndromes[J].Chinese Heart Journal,2011,23(5):629-632. |
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| Authors: | WANG Ai-ping ZHANG Huan-yi YANG Shu-guang WU Yun WANG Yong-mei ZHANG Dai-min |
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| Institution: | WANG Ai-ping1,ZHANG Huan-yi1,YANG Shu-guang2,WU Yun1,WANG Yong-mei1,ZHANG Dai-min2(1.Department of Cardiology,Taian Central Hospital,Taian 271000,Shandong,China,2.Department of Cardiology,PLA 88th Hospital,China) |
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| Abstract: | AIM: To investigate the association between serum N-terminal pro-B-type natriuretic peptide(NT-proBNP) levels and the severity of coronary artery lesions.METHODS: Serum NT-proBNP concentrations and left ventricular ejection fraction(LVEF) were measured in 150 patients with chest pain.All patients underwent coronary artery angiography(CAG).Severity of coronary artery lesions was estimated by coronary angiographic Gensini score.According to clinical data and results of CAG,78 patients were diagnosed with ACS,... |
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| Keywords: | acute coronary syndromes serum NT-proBNP LVEF coronary artery angiography coronary artery lesions |
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