Uncovered: the family relationship of a T-cell-membrane protein and bacterial toxins |
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| Affiliation: | 1. Dipartimento di Scienze degli Alimenti e del Farmaco, Università di Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy;2. Dipartimento di Medicina e Chirurgia, Unità di Neuroscienze, Università di Parma, Via Volturno 39/F, 43125 Parma, Italy;3. Division of Translational Medicine & Human Genetics, Perelman School of Medicine at the University of Pennsylvania, 3600 Spruce Street, Philadelphia, PA 19104, USA;1. Department of Pharmacology, Key Laboratory of Neuropsychiatric Diseases, China Pharmaceutical University, Nanjing 210009, China;2. Department of Drug Discovery and Development, School of Pharmacy, Auburn University, Auburn, AL, USA |
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| Abstract: | Mono-ADP-ribosylation was originally discovered as the mechanism by which diphtheria toxin inactivates protein synthesis. It is now apparent that higher organisms use analogous mechanisms to regulate endogenous metabolism. Here, the relationship between bacterial toxins and vertebrate mono-ADP ribosyltransferases is explored. |
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