Inflammatory and immunological parameters of disease activity in rheumatoid arthritis patients treated with minocycline |
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| Affiliation: | 1. The Society for the Investigation of Early Pregnancy (SIEP), Cherry Hill, NJ, USA;2. BioIncept LLC, Cherry Hill, NJ, USA;3. Department of Bone Marrow Transplantation and Cancer Immunotherapy, Hadassah University Hospital Ein Kerem, Hebrew University, Jerusalem, Israel;4. Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA;5. Department of Obstetrics and Gynecology, University Hospital Bern, Bern, Switzerland;6. Catholic University of Sacred Heart, Institute of General Pathology, Rome, Italy;7. Yale Women and Children''s Center for Blood Disorders, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA;1. Dpt. of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czechia;2. Dpt. of Neurology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czechia;3. Value Outcomes s.r.o., Prague, Czechia;4. Dpt of Neurology, KZ a.s., Hospital Teplice, Teplice, Czechia;5. Clinic of Neurology, University Hospital Ostrava, Ostrava, Czechia;6. Dpt. of Neurology, Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Hradec Kralove, Czechia;7. Dpt. of Neurology, Charles University in Prague, Faculty of Medicine in Pilsen and University Hospital Pilsen, Pilsen, Czechia;8. Neurology Clinic, Pardubice Regional Hospital and Faculty of Health Studies, University of Pardubice, Pardubice, Czechia;9. Dpt. of Neurology, Hospital of Jihlava, Jihlava, Czechia;10. Dpt. of Neurology, Thomayer Hospital, Prague, Czechia;11. Charles University in Prague, Third Faculty of Medicine, Charles University and Hospital Kralovske Vinohrady, Prague, Czechia;12. Dpt. of Neurology, University Hospital and Masaryk University, Brno, Czechia;13. Dpt. of Neurology, Faculty of Medicine, Palacky University and University Hospital Olomouc, Olomouc, Czechia;14. First Dpt. of Neurology, Masaryk University, St. Anne''s University Hospital, Brno, Czechia;15. Dpt. of Neurology, Tomas Bata Regional Hospital, Zlin, Czechia;p. Dpt. od Neurology, Hospital Ceske Budejovice, Ceske Budejovice, Czechia;q. Dpt. of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czechia |
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| Abstract: | ![]()
The objective of this study was to analyze the anti-inflammatory effect of minocycline in rheumatoid arthritis. Serum samples of 65 RA patients who completed a 26-week randomized double-blind trial of minocycline (100 mg twice a day) versus placebo were studied. In this trial some clinical parameters and in particular the acute phase response decreased significantly in the minocycline-treated group. Serum levels of albumin and interleukin-6 (IL-6) were compared with CRP levels in order to study the acute phase response. Furthermore, rheumatoid factor (RF) and total immunoglobulin isotypes as well as serum levels of soluble interleukin-2 receptor (sIL2-2R) were determined in order to study immunological parameters of the disease. Immunoglobulins and cytokines were measured by ELISA. Serum levels of albumin remained stable, whereas serum CRP levels decreased both in the minocycline- and in the placebo-treated group. Serum levels of IL-6 decreased in the minocycline-treated group only and this decrease was positively correlated with the decrease in CRP levels. Minocycline significantly decreased serum IgM-RF, IgA-RF, total IgM and total IgA levels. In addition the ratio of IgM-RF/total IgM decreased in the minocycline-treated group. No such changes were observed in the placebo-treated group. The anti-inflammatory effect of minocycline in RA patients may be due to the reduction in the synthesis of IL-6 and rheumatoid factor. |
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