厄贝沙坦联合氨氯地平对老年原发性高血压合并T2DM患者血清Hcy及BNP水平的影响

目的探讨厄贝沙坦联合氨氯地平对老年原发性高血压合并2型糖尿病患者血清同型半胱氨酸及脑钠肽水平的影响.方法将120例老年原发性高血压合并2型糖尿病患者按随机数字表法分为甲、乙、丙3组,每组40例,甲组予以氨氯地平联合厄贝沙坦治疗,乙组予以厄贝沙坦治疗,丙组予以氨氯地平治疗.于治疗前后采用酶联免疫吸附法测定血清同型半胱氨酸水平,采用快速荧光免疫法测定血清脑钠肽水平,采用血浆葡萄糖氧化酶法检测空腹血糖和餐后2 h血糖,同时测量患者静息状态血压.结果治疗后3组患者血压、血清同型半胱氨酸、血清脑钠肽、空腹血糖及餐后2 h血糖水平均较治疗前显著降低(P<0.05或0.01),甲组显著低于乙组、丙组(P<0.01).结论厄贝沙坦联合氨氯地平治疗老年原发性高血压合并2型糖尿病能有效控制患者血压及血糖水平,降低血清同型半胱氨酸及脑钠肽水平,优于单用氨氯地平或厄贝沙坦治疗.

Effects of irbesartan and amlodipine on Hcy and BNP levels in essential hypertensive elderly patients with T2DM

Objective To investigate the effect of irbesartan and amlodipine on the levels of homocysteine(Hcy)and brain natriuretic peptide(BNP)in essential hypertensive elderly patients with type 2 diabetes mellitus(T2DM).Methods 120 cases of elderly patients with essential hypertension with T2DM were were randomly divided into three groups according to random number table method,40 cases each.Group A was given amlodipine combined with irbesartan,group B was treated with irbesartan alone,group C was treated with amlodipine alone.Serum homocysteine was measured by enzyme-linked immunosorbent assay before and after treatment,and serum brain natriuretic peptide levels were measured by rapid fluorescent immunoassay.Plasma glucose oxidase method was used to measure fasting blood glucose and 2 h postprandial blood glucose.At the same time,the patien'ts resting blood pressure was measured.Results After treatment,the blood pressure,serum Hcy,serum BNP,fasting blood glucose,and 2 h postprandial blood glucose levels in the three groups were significantly lower than before treatment(P<0.05 or 0.01).Group A was significantly lower than group B and group C(P<0.01).Conclusions Irbesartan combined with amlodipine in the treatment of elderly patients with essential hypertension combined with type 2 diabetes can effectively control blood pressure and blood sugar levels,reduce serum homocysteine and brain natriuretic peptide levels,which is better than that of amlodipine or irbesartan alone.