Epidemiology of gout and hyperuricemia in New Caledonia |
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| Institution: | 1. Department of Rheumatology, Lariboisière hospital APHP Paris Nord, and Université de Paris, INSERM U1132, Paris, France;2. Agence Sanitaire et Sociale, Nouméa, New Caledonia;3. Soladis Clinical Studies, Roubaix, France;1. Department of Rheumatology, CHRU de Besançon, 3, boulevard Fleming, 25000 Besançon, France;2. EA 4267 “PEPITE”, UFR Santé, Franche-Comté University, 19, rue Ambroise Paré, bâtiment S, 25030 Besançon cedex, France;3. EA 4266 « EPILAB », UFR Santé, Franche-Comté University, 19, rue Ambroise Paré, bâtiment S, 25030 Besançon cedex, France;1. Department of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, 563000 Zunyi, China;2. Department of Endocrinology, Affiliated Hospital of Zunyi Medical University, 563000 Zunyi, China;1. Department of infectious diseases, Avicenne Hospital, Bobigny, France;2. Department of rheumatology, Avicenne Hospital, Bobigny, France;3. Department of microbiology, Avicenne Hospital, Bobigny, France;1. Rheumatology Department, Nantes University Hospital, Hôtel-Dieu, Place Alexis-Ricordeau, 44093 Nantes Cedex 01, France;2. Rheumatology Department & Inserm UMR 1132 (centre Viggo Petersen), Hôpital Lariboisière, 2, rue Ambroise Paré, 75010 Paris, France;3. Université de Paris, UFR de Médecine, 75010 Paris, France;4. Service de rhumatologie, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France;5. RESO: Centre de Référence des Maladies Autoimmunes Systémiques Rares Est Sud-Ouest, Strasbourg, France;6. INSERM UMR_S1109, Université de Strasbourg, 67000 Strasbourg, France;1. ENT department, Charles-Nicolle Hospital, Boulevard du 9-Avril 1938, 1006 Tunis, Tunisia;2. Faculty of medicine of Tunis, University Tunis-el-Manar, Tunis, Tunisia;1. Université de Tours, Tours, France;2. Service de rhumatologie, CHRU de Tours, 37044 Tours cedex, France;3. Service de médecine intensive réanimation, CHRU de Tours, Tours, France;4. Service de médecine interne, CHRU de Tours, Tours, France;5. Service d’information médicale, d’épidémiologie et d’économie de la santé, CHRU de Tours, 37000 Tours, France |
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| Abstract: | ObjectivesNew Caledonia is a Pacific island of 270,000 inhabitants with mixed ethnicities, including Polynesians (10.2%), people from European ancestry (27.2%), and Melanesians (39.1%),. This study aimed at determining the prevalence of gout and hyperuricemia in the general population and the various ethnicities of New Caledonia.MethodsA 3-degree random sample of the population aged 18 to 60 years was adjusted according to the 2014 New Caledonia census. Face-to-face planned interviews and physical measurements were performed by trained nurses. All consenting participants underwent capillary measurement of creatinine; all consenting men and only women older than 40 years underwent point-of-care uricemia testing. Gout was defined by a validated algorithm. Two definitions of hyperuricemia were used: capillary level equivalent to plasma uric acid level > 360 μmol/l (6 mg/dl) and > 420 μmol/l (7 mg/dl) and/or urate-lowering drug treatment for both thresholds.ResultsWe included 1144 participants (adjusted mean age 37.7 ± 12.0 years; adjusted sex ratio 50.4% men). The adjusted prevalence of gout was 3.3% (95% confidence interval 2.2–4.9). Prevalence was 6.7% (2.5–16.8), 4.1% (1.8–8.9), and 2.6% (1.4–4.7) for Polynesians, Europeans and Melanesians, respectively, and 1.9% (0.5–6.6) for other ethnicities. Prevalence of hyperuricemia, determined in 658 participants, was 67.0% (61.9–71.6) and 37.0% (32.3–42.0) for the 360- and 420-μmol/l thresholds, respectively, and was significantly greater for Polynesians and Melanesians than Europeans for both thresholds.ConclusionsThe prevalence of gout and hyperuricemia in New Caledonia was high, including in patients of European descent. |
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| Keywords: | Gout Hyperuricemia Epidemiology New Caledonia Melanesians Polynesians |
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