Primary central nervous system Hodgkin lymphoma: A case report and review of the literature |
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| Affiliation: | 1. Department of Neurosurgery, Consorcio Hospital General Universitario de Valencia, 46014 Valencia, Spain;2. Department of Diagnostic Pathology, Consorcio Hospital General Universitario de Valencia, 46014 Valencia, Spain;1. Mersin University, Faculty of Medicine, Division of Pediatric Neurology, Mersin, Turkey;2. Mers?n University, Faculty of Medicine, Biostatistics and Bioinformatics, Mersin, Turkey;1. Department of Neurosurgery, School of Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran;2. Pharmaceutical Care Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran;3. Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran;1. Department of Orthopaedic Surgery, Hospital Nacional de Parapléjicos, Toledo, Spain;2. Department of Neurosurgery, Royal Sussex County Hospital, Brighton, United Kingdom;3. Research Department, Instituto de Ciencias de la Salud, Talavera de la Reina, Toledo, Spain;1. Servicio de Neurocirugía, Hospital Universitario Virgen de las Nieves, Granada, España;2. Servicio de Anestesiología y Reanimación, Hospital Universitario Virgen de las Nieves, Granada, España;3. Medtronic Ibérica S.A.;4. Unidad de Gestión Clínica de Neurocirugía, Hospital Universitario Virgen de las Nieves, Granada, España |
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| Abstract: | ![]()
Central nervous system (CNS) involvement in the context of relapsed/refractory Hodgkin lymphoma (HL) is a quite rare, but well-known complication. Nevertheless, primary CNS–HL is an exceedingly rare condition, which diagnosis is based on well-defined morphological and immunohistochemical features, in addition to isolated involvement of the CNS.In spite of limited casuistry (just over twenty cases reported in the literature), available data agree that primary and isolated CNS–HL, when treated with a combination of surgery followed by some form of adjuvant therapy (radiotherapy ± chemotherapy), carries a better prognosis than those cases with CNS involvement in the context of relapsed/refractory HL or those with CNS non-Hodgkin lymphoma.We herein report a case of a 55-year-old female patient who was diagnosed with primary CNS–HL. The patient was treated with complete surgical resection followed by intrathecal chemotherapy and whole brain radiotherapy (WBRT), showing fourteen months of disease-free survival at the time of this case report. A review of the available literature is also presented. |
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| Keywords: | Hodgkin lymphoma Primary lymphoma Central nervous system Brain neoplasm Histology Immunohistochemistry Linfoma de Hodgkin Linfoma primario Sistema nervioso central Tumor cerebral Histología Inmunohistoquímica |
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