我院2005～2006年519例真菌耐药性分析

目的:了解我院真菌感染的特点及药物敏感情况。方法:常规培养分离真菌,用VITEK全自动微生物分析仪鉴定到种,药敏试验采用Rosco抗真菌药敏纸片扩散法及NCCLSM27-A肉汤稀释法。结果:519株真菌全为酵母菌属,白色念珠菌占70.3%。制霉菌素敏感性最好,其次为两性霉素B,氟康唑、伊曲康唑敏感性不理想。结论:当前临床常用抗真菌药耐药菌株明显增多,进行真菌药敏监测势在必行。

Analysis of Drug Resistance of 519 Strains of Fungus in Our Hospital from 2005 to 2006

OBJECTIVE： To study the feature of fungus infection and the drug susceptibility for the fungus in our hospital, METHODS： Fungi were cultured and isolated by routine procedure and identified by VITEK microbe automatic system. Drug susceptibility test was performed using Rosco paper disk diffusion and broth dilution method with NCCLS M27- A. RESULTS： 519 strains of fungi were all Blastocystis, with Monilia albieans making up 70.3%. Mycostatin showed the highest susceptibility, followed by amphotericin B. Fluconazol and itraconazole showed poor susceptibility. CONCLUSION： The resistant strains to common antifungal drugs experienced an obvious increase in clinical practice; therefore, it is imperative to monitor the drug susceptibility of fungi.