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Challenges in design of multicenter trials: end points assessed longitudinally for change and monotonicity
Authors:Dyck Peter J  Norell Jane E  Tritschler Hans  Schuette Klemens  Samigullin Rustem  Ziegler Dan  Bastyr Edward J  Litchy William J  O'Brien Peter C
Affiliation:Peripheral Neuropathy Research Laboratories, Mayo Clinic College of Medicine, 200 First St., SW, Rochester, MN 55905, USA. dyck.peter@mayo.edu
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