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Extracorporeal Membrane Oxygenation Can Save Lives in Children With Heart or Lung Failure After Liver Transplantation
Authors:Sandrine Jean  Christophe Chardot  Mehdi Oualha  Carmen Capito  Olivier Bustarret  Philippe Pouard  Sylvain Renolleau  Florence Lacaille  Laurent Dupic
Institution:1. Pediatric Intensive Care Unit, H?pital Armand‐Trousseau, Paris, France;2. Department of Surgery, H?pital Universitaire Necker‐Enfants Malades, Paris, ?le‐de‐France, France;3. Pediatric Intensive Care Unit, H?pital Universitaire Necker‐Enfants Malades, Paris, ?le‐de‐France, France;4. Cardiac Surgery Intensive Care, H?pital Universitaire Necker‐Enfants Malades, Paris, ?le‐de‐France, France;5. Department of Gastroenterology, Hepatology and Nutrition, H?pital Universitaire Necker‐Enfants Malades, Paris, ?le‐de‐France, France
Abstract:The risk of cardiac or lung failure after liver transplantation (LT) is significant. In rare cases, the usual intensive care techniques fail to maintain organ oxygenation with a risk of multiorgan dysfunction. Although extracorporeal membrane oxygenation (ECMO) is a difficult and risky procedure, it can be proposed as life‐saving. Four children with either acute pulmonary (three) or cardiac (one) failure after LT, and the criteria that decided the use of ECMO (level of ventilation and results, dosage of inotropic drugs, cardiac ultrasound, blood lactate) were retrospectively reported. These patients, 1–11 years old, were treated with either veno‐arterial (three) or veno‐venous (one) ECMO. Two experienced a full recovery, with 3 and 6 years of follow‐up. Two died of systemic inflammatory response syndrome (SIRS) due to ECMO, and relapse of heart failure due to the underlying disease. Although our patients' survival was only 50%, we showed that ECMO can be useful in children after LT. It should be considered before the development of irreversible multiorgan failure.
Keywords:Liver transplantation  Extracorporeal membrane oxygenation  Heart failure  Respiratory insufficiency  Pediatric
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