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| 抗角蛋白自身抗体对豚鼠银屑病样模型的影响 | |
| 引用本文： | 李冰,李巍,刘玉峰,李承新,赵小东,高天文. 抗角蛋白自身抗体对豚鼠银屑病样模型的影响[J]. 中国皮肤性病学杂志, 2002, 16(2): 73-75 |
| 作者姓名： | 李冰 李巍 刘玉峰 李承新 赵小东 高天文 |
| 作者单位： | 第四军医大学西京医院皮肤科,陕西,西安,710032 |
| 基金项目： | 10 35工程 (国家新药研究与产业化开发项目 )资助课题(编号 96 - 90 1 - 0 1 -38) |
| 摘 要： | 目的：观察抗角蛋白自身抗体对（anti keratin autoantibody,AK auto Ab）对豚鼠银屑病样模型的作用。方法：应用心得安法制备豚鼠耳廓银屑病样模型，采用亲和层析法纯化的正常人AKatuoAb，以肌肉注射方式给药，从组织病理变化评价治疗效果。结果AKatuoAb组动物银现样改变的恢复程度明显优于对照组（P＜0．0001），动物血清中可检测人到AKatuoAb。结论：提示AKatuoAb具有促进及鼠银屑病样模型恢复的作用。 |
| 关 键 词： | 抗角蛋白自身抗体对 银屑病 动物模型 |
| 文章编号： | 1001-7089(2002)02-0073-03 |
| 修稿时间： | 2000-10-24 |
Effect of AK auto Ab on Psoriasis-like Model of Guinea-pig |
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| LI Bing,LI Wei,LIU Yu-feng,et al. Effect of AK auto Ab on Psoriasis-like Model of Guinea-pig[J]. The Chinese Journal of Dermatovenereology, 2002, 16(2): 73-75 | |
| Authors: | LI Bing LI Wei LIU Yu-feng et al |
| Affiliation: | LI Bing,LI Wei,LIU Yu-feng,et al Department of Dermatology,Xijing Hospital,Fourth Military Medical University,Xi'an 710032,China |
| Abstract: | Objective To investigate the effect of AK auto Ab on psoriasis-like model of guinea-pig.Methods Propranolol was applied to make the psoriasis-like model of guinea-pig.AK auto Ab purified from pooled serum of healthy human by chromatography was given to animals through intramuscular injection,with immunoglobulin without AK auto Ab as control.Effect of AK auto Ab was analyzed by means of histological score.Results Psoriasis-like model of guinea-pig in AK auto Ab groups had a faster recovery than that of the controls,and human AK auto Ab was detected in sera of guinea-pig.Conclusion It suggeste that AK auto Ab can improve the recovery of psoriasis-like model of guinea-pig. |
| Keywords: | AK auto Ab Psoriasis Animal model |
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