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| IL-18基因多态性与原发性干燥综合征的相关性 | |
| 引用本文： | 李恩泽,辛苗苗,胡彬,闫丽萍,李慧. IL-18基因多态性与原发性干燥综合征的相关性[J]. 青岛大学医学院学报, 2010, 46(4): 333-335,338. DOI: 10.3969/j.issn.1672-4488.2010.04.017 |
| 作者姓名： | 李恩泽 辛苗苗 胡彬 闫丽萍 李慧 |
| 作者单位： | 青岛大学医学院附属医院药剂科,山东,青岛,266003;青岛市中心血站;青岛市中心医院 |
| 摘 要： | 目的探讨IL-18基因-137G/C、-607C/A位点多态性及其血清水平与原发性干燥综合征的相关性。方法提取受试者白细胞DNA,采用聚合酶链反应-限制性片段长度多态性技术检测28例原发性干燥综合征病人和52例健康对照者IL-18基因-607C/A、-137G/C位点多态性,酶联免疫吸附(ELISA)法检测两组血清IL-18含量。结果两组IL-18基因-137G/C、-607C/A位点基因型频率及等位基因频率比较差异均无显著性(P>0.05)。原发性干燥综合征组血清IL-18水平明显低于健康对照组,差异有显著性(t=24.06,P<0.001)。原发性干燥综合征组不同基因型间血清IL-18水平比较差异均无显著性(P>0.05)。结论血清IL-18水平表达降低可能是原发性干燥综合征的促发因素。 |
| 关 键 词： | 白细胞介素18 基因型 基因频率 原发性干燥综合征 |
CORRELATION BETWEEN POLYMORPHISMS OF THE INTERLEUKIN-18 GENE AND PRIMARY SJOGREN'S SYNDROME |
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| LI EN-ZE,XIN MIAO-MIAO,HU BIN,et al. CORRELATION BETWEEN POLYMORPHISMS OF THE INTERLEUKIN-18 GENE AND PRIMARY SJOGREN'S SYNDROME[J]. Acta Academiae Medicinae Qingdao Universitatis, 2010, 46(4): 333-335,338. DOI: 10.3969/j.issn.1672-4488.2010.04.017 | |
| Authors: | LI EN-ZE XIN MIAO-MIAO HU BIN et al |
| Affiliation: | LI EN-ZE,XIN MIAO-MIAO,HU BIN,et al(The Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,China) |
| Abstract: | Objective To investigate the association of polymorphisms of-607C/A,-137G/C promoters of IL-18 gene and its serum level with primary Sjogren's syndrome. Methods The DNA of white blood cells were extracted from subjects,polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) method was applied to detect polymorphisms of-607C/A,-137G/C promoters of IL-18 gene in 28 patients with primary Sjogren's syndrome(group A) and 52 healthy controls(group B);serum IL-18 was measured in both groups by... |
| Keywords: | interleukin-18 genotype gene frequency Sjogren's syndrome |
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