喉癌发生发展过程中TRAIL和Survivin蛋白的表达研究

目的：探讨喉癌发生发展过程中TRAIL、Survivin蛋白的表达及与喉癌病理特征的关系。方法：采用免疫组化SP法对48例喉癌患者手术后大体标本中喉正常黏膜、不典型增生及浸润癌组织进行检测及分析。结果：TRAIL蛋白从正常黏膜-不典型增生-浸润癌呈渐进性低表达，而Survivin蛋白则呈渐进性高表达。喉浸润癌组织中TRAIL蛋白的低表达与Survivin蛋白的高表达呈负相关(r=-0.510, P<0.01)。结论：TRAIL和Survivin两种蛋白参与了喉癌的发生发展，两者的表达失调与喉癌发生密切相关。

Expression of TRAIL and Survivin proteins in the carcinogenesis and development of laryngeal carcinoma

Objective: To explore the correlation between the expressions of TRAIL and Survivin proteins and the pathologic features of laryngeal epithelial lesions. Methods: Immunohistochemistry was used to determine the expressions of TRAIL and Survivin proteins in normal mucosa and displasia and invasive carcinoma tissues of 48 cases of laryngeal carcinoma. Results: The expression of Survivin protein progressively increased, whereas that of TRAIL protein gradually decreased in a route of normal mucosa and displasia and invasive carcinoma tissues. The expression of TRAIL protein in laryngeal invasive carcinoma was negatively correlated with that of Survivin protein (r=-0.510, P<0.01). Conclusions: The expressions of TRAIL and Survivin proteins are significantly related to the genesis and progression of laryngeal carcinoma.