新型卤酚类化合物的合成及其体外抗氧化活性研究

目的 合成具有新型结构的系列卤酚类化合物，测定其体外抗氧化活性并初步探讨其构效关系。 方法 以取代苯甲酸或苯甲酰氯为原料，经多步反应制得卤酚类化合物，并通过DPPH（二苯代苦味肼基）自由基清除实验测定其抗氧化活性。 结果与结论 9个目标化合物均为首次合成的新化合物，其结构经ESI-MS、1H-NMR、13C-NMR确证，总收率70%~91%。体外活性实验表明，抗氧化活性与羟基和卤原子的数目与位置有关；化合物5c，5c’，8b，8c的抗氧化活性优于常用抗氧化剂BHT（二丁基羟基甲苯）。

Synthesis and in vitro antioxidative activity of novel halophenols

Aim To design and synthesize derivatives of marine natural product halophenols,to test their in vitro antioxidative activity.Methods Halophenols were prepared from benzoyl chlorides or benzoic acids with different synthetic routes.1,1-Diphenyl-2-picrylhydrazyl(DPPH) radical-scavenging activity of target compounds was evaluated.Results and conclusion Nine new compounds were synthesized with total yield from 70% to 91%.The structures were characterized by ESI-MS,1H-NMR,and 13C-NMR spectra.The preliminary assa...