EEG changes after fluphenazine enanthate and decanoate based on analog power spectra and digital computer period analysis

Quantitative EEG investigations, using an analog frequency analyzer and digital computer period analysis, were carried out following single parenteral injection of two long-acting fluphenazine derivatives, decanoate and enanthate. Both quantitative methods of analysis demonstrated that fluphenazine decanoate and enanthate produce significant EEG alterations which are similar to changes induced both by fluphenazine hydrochloride and by other known major tranquilizers (EEG profile of major tranquilizers). Maximum EEG changes occurred during the first week after enanthate, while they occurred during the second week following decanoate injection. These findings confirmed the metabolic and behavioral studies in animals regarding the long action of both compounds and, in particular, they demonstrated that the activity of fluphenazine decanoate is longer in duration than fluphenazine enanthate.Supported, in part, by the Psychiatric Research Foundation of Missouri and the Squibb Institute for Medical Research, New Brunswick, N.J. 08903. Presented, in part, at The 7 th Congress of Collegium Internationale Neuropsychopharmacologicum, August 11–13, 1970, Prague.