5-羟色胺2A受体基因多态性与强迫症的关系

目的探讨上海地区汉族人口中5羟色胺2A受体(5HT2A)基因多态性同强迫症的关系。方法采用PCRRFLP技术测定124例强迫症患者和104例健康对照的基因型;根据SCIDII评定结果对强迫症患者进行亚组划分。结果强迫症患者5HT2A的3种基因型(A1/A1、A1/A2和A2/A2)频率分别为25.0%、54.8%和20.2%,健康对照组分别为28.8%、45.2%和26.0%,两组之间无显著差异(P>0.05)。不伴有强迫人格的患者5HT2A基因型与对照组存在显著性差异(P<0.05),而伴有强迫人格的患者基因型分布与健康对照之间无显著性差异(P>0.05)。结论在上海汉族人群中5HT2A基因可能与无强迫型人格障碍的强迫症存在关联,有强迫人格和无强迫人格的患者可能有不同的发病机制。

Association Analysis of Serotonin 2A Receptor Gene Polymorphism and Obsessive-Compulsive Disorder

Objective To explore the relationship between polymorphism of serotonin 2A receptor gene (5-HT2A) and obsessive-compulsive disorder(OCD) in the Han nationality of Shanghai. Methods One hundred and twenty-four OCD patients and 104 healthy controls were included in this study. All subjects were genotyped directly via polymerase chain reaction and restriction fragment length polymorphism techniques. SCID-II was used to evaluate the comorbidity of OCD and personality disorders. Results The frequencies of three T102C genotypes of 5-HT2A receptor gene (A1/A1, A1/A2 and A2/A2) were 25.0%, 54.8% and 20.2%, respectively, in the OCD patients, and 28.8%, 45.2% and 26.0%,respectively, in the controls. There were no significant differences of genotype and allele frequencies of 5-HT2A between the OCD patients and controls (P>0.05). If the patients were divided into two subgroups according to SCID-II, there were significant differences of 5-HT2A genotype between patients without obsessive compulsive personality disorder(OCPD) and controls (P<0.05), while no significant differences of genotype or allele frequency between patients with OCPD and controls (P>0.05). Conclusion The polymorphism of 5-HT2A receptor gene maybe associated with OCD patients who do not have OCPD in the Han nationality. Patients with or without OCPD may have different etiology.