首页 | 本学科首页   官方微博 | 高级检索  
     


High-dose combination cyclophosphamide,cisplatin, and melphalan with autologous bone marrow support
Authors:William P. Peters  Ann Stuart  Mary Klotman  Colleen Gilbert  Roy B. Jones  Elizabeth J. Shpall  Jon Gockerman  Robert C. Bast Jr.  Joseph O. Moore
Affiliation:(1) Bone Marrow Transplant Program, Duke University Medical Center, Department of Medicine, 27710 Durham, NC, USA
Abstract:
Summary A total of 23 patients were treated at five dose escalations with high-dose combination cyclophosphamide, cisplatin, and melphalan with autologous bone marrow support. The maximum tolerated doses of cyclophosphamide, cisplatin, and melphalan were 5,625, 180, and 80 mg/m2, respectively. The dose-limiting toxicity was cardiac toxicity. Objective tumor regression occurred in 14 of 18 evaluable cases, with a median duration of 3.5 months. Pharmacokinetic evaluation of melphalan in 20 patients revealed a dose-related increase in maximum plasma concentration (Cmax) and area under the curve (AUC). Perturbation of the melphalan plasma half-life and AUC, associated with severe toxicity, resulted when renal insufficiency occurred. The results suggest that high-dose combination cyclophosphamide, cisplatin, and melphalan produces frequent, rapid responses in breast cancer, melanoma, and sarcoma, although with significant extramedullary toxicity. The pharmacokinetics suggest that modification of the treatment schedule may result in a reduction of treatment-related toxicity.Supported in part by grant 5-PO1-CA32672 from the National Cancer Institute
Keywords:
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号