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结核病免疫应答中自噬现象的分子机制和意义
引用本文:黄丹丹,鲍朗. 结核病免疫应答中自噬现象的分子机制和意义[J]. 国际免疫学杂志, 2012, 35(4): 249-254. DOI: 10.3760/cma.j.issn.1673-4394.2012.04.002
作者姓名:黄丹丹  鲍朗
作者单位:1.四川大学华西基础医学与法医学院感染免疫研究室,成都,610041;2.四川大学华西基础医学与法医学院感染免疫研究室,成都,610041
基金项目:国家传染病重大专项资助项目,国家自然科学基金资助项目
摘    要:越来越多的证据表明,自噬是结核免疫反应的重要组成部分.自噬可以杀灭结核分枝杆菌、调节促炎细胞因子的分泌、增加抗原递呈功能.自噬与其他抗菌途径如维生素D3、炎性体、泛素系统存在协同作用.另一方面,结核分枝杆菌可以调控巨噬细胞的自噬.目前,自噬已成为临床重要的诊疗靶点.其能诱导自噬的药物,可以作为佐剂治疗耐药性结核;能有效诱导自噬的疫苗,可能提供更好的免疫保护作用.

关 键 词:自噬  结核分枝杆菌  免疫

The molecular mechanism and significance of autophagy in immune response to mycobacterium tuberculosis
HUANG Dan-dan , BAO Lang. The molecular mechanism and significance of autophagy in immune response to mycobacterium tuberculosis[J]. International Journal of Immunology, 2012, 35(4): 249-254. DOI: 10.3760/cma.j.issn.1673-4394.2012.04.002
Authors:HUANG Dan-dan    BAO Lang
Affiliation:. Department of Infection and Immunity, West China School of Preclini- cal and Forensic Medicine , Sichuan University, Chengdu 610041, China
Abstract:A growing body of evidence shows that autophagy is an essential component in the immune response to Mycobacterium tuberculosis (Mtb). Autophagy, a direct mechanism of killing intracellular Mycobacterium tuberculosis, acts as a modulator of proinflammatory cytokine secretion and plays a key role in antigen presentation. Autophagy coordinate with other host immune strategies against mycobacteria, including vitamin D-mediated innate immunity, ubiquitin-and inflammasome-involved pathways. On the other hand, Mtb has its strategies to modulate the autophagy in macrophage. Autophagy offers an attractive therapeutic target. Autophagy-promoting agents could have a clinical application as adjunctive treatment for drug-resistant tuberculosis. Moreover, vaccines which effectively induce autophagy could be more successful in providing better immune protection.
Keywords:Autophagy  Mycobacterium tuberculosis  Immunity
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