| IL-33及其受体ST2在炎症性肠病中免疫调节作用的研究新进展 |
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| 引用本文： | 刘天聪,王大南,吕昌龙. IL-33及其受体ST2在炎症性肠病中免疫调节作用的研究新进展[J]. 国际免疫学杂志, 2012, 35(4): 269-272. DOI: 10.3760/cma.j.issn.1673-4394.2012.04.006 |
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| 作者姓名： | 刘天聪 王大南 吕昌龙 |
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| 作者单位： | 1.中国医科大学免疫研究所,沈阳,110001;2.中国医科大学免疫研究所,沈阳,110001;3.中国医科大学免疫研究所,沈阳,110001 |
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| 摘 要： | IL-33是近年来发现的一种IL-1家族的细胞因子,其受体为ST2.IL-33具有双重作用,既能作为分泌性细胞因子,参与调节Th2型免疫应答,诱导前炎性因子的表达,又能作为核因子,定位于细胞核内,起抑制转录作用,阻遏前炎性基因表达.在慢性炎症性肠病(IBD)患者的肠道组织中可查到该细胞因子的表达.研究IL-33及ST2受体有助于进一步了解IBD发病机制,寻找治疗IBD的新靶点.
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| 关 键 词： | IL-33 ST2受体 炎症性肠病 细胞因子 |
Progress in immunoregulatory effects of IL-33 and its receptor ST2 on inflammatory bowel diseases |
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| LIU Tian-cong , Wang Da-nan , L Chang-long. Progress in immunoregulatory effects of IL-33 and its receptor ST2 on inflammatory bowel diseases[J]. International Journal of Immunology, 2012, 35(4): 269-272. DOI: 10.3760/cma.j.issn.1673-4394.2012.04.006 |
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| Authors: | LIU Tian-cong Wang Da-nan L Chang-long |
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| Affiliation: | LIU Tian-cong , Wang Da-nan , L(U) Chang-long |
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| Abstract: | Interleukin 33 （ IL-33 ） is a kind of cytokine which was designated as a novel member of in- terleukin-1 （ IL-1 ） family with its receptor ST2. IL-33 exhibits dual role, as a secreted cytokines, it can be involved in eliciting a Th2-1ike cytokine response by interacting with ST2L, and induce the impression of proinflammatory cytokines. In addition, as a nuclear factor, it locates in the nucleus , represses transcriptional activation and dampenes proinflammatory signaling. IL-33 can be found in the intestinal mucosa of patients suffering inflammatory bowel disease. Exploration of the function of IL-33 and ST2L might contribute to define the mechanism of IBD and find new rational therapeutic targets for the treatment. |
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| Keywords: | Interleukin-33 ST2L Inflammatory bowel disease Cytokines |
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