| 细胞间黏附分子-1的研究概况及临床意义 |
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| 引用本文： | 岳峰,雷呈祥. 细胞间黏附分子-1的研究概况及临床意义[J]. 国际免疫学杂志, 2012, 35(2): 107-112. DOI: 10.3760/cma.j.issn.1673-4394.2012.02.007 |
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| 作者姓名： | 岳峰 雷呈祥 |
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| 作者单位： | 1.海军医学研究所,上海,200433;2.海军医学研究所,上海,200433 |
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| 摘 要： | 细胞间黏附分子-1( ICAM-1)是一种细胞表面的跨膜糖蛋白,可介导细胞与细胞间或细胞与细胞外基质之间的相互作用.ICAM-1广泛地参与细胞黏附、炎症的发生发展、信号转导和肿瘤转移等多种重要的生理及病理过程.在临床上,ICAM-1可作为多种炎症或肿瘤发展和预后的重要生物标记物之一.以ICAM-1为靶点的药物或能预防和治疗多种急、慢性炎症引起的组织损伤和肿瘤等.
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| 关 键 词： | 细胞间黏附分子-1 细胞黏附 炎症 |
Review of intercellular adhesion molecule-1 and its clinical significance |
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| YUE Feng , LEI Cheng-xiang. Review of intercellular adhesion molecule-1 and its clinical significance[J]. International Journal of Immunology, 2012, 35(2): 107-112. DOI: 10.3760/cma.j.issn.1673-4394.2012.02.007 |
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| Authors: | YUE Feng LEI Cheng-xiang |
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| Affiliation: | . Institute of Naval Medicine, Shanghai 200433, China |
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| Abstract: | Intercellular adhesion molecule-1 （ ICAM-1 ） is a surface glycosylated transmembrane protein that mediates the adhesion between ceils and between cell and extracellular matrix. ICAM-1 is widely involved in the regulation of multitude cellular functions, such as cell adhesion, inflammation, signal transduetion and tumor metastasis. Clinically, ICAM-1 can be considered to be one of the key biomarkers for many kinds of inflammation and tumor relapse and prognosis. The drugs and medications that target ICAM-1 might be used to prevent and treat tumors and tissue damages cansed by various acute and chronic inflammation. |
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| Keywords: | ICAM-1 Cell adhesion Inflammation |
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