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International nifedipine trial on antiatherosclerotic therapy (intact)
Authors:Professor Dr. Paul Robert Lichtlen  Ulrich Nellessen  Wolfgang Rafflenbeul  Stefan Jost  Hartmut Hecker
Affiliation:(1) Department of Cardiology, Hannover Medical School, Hannover, FRG;(2) Abterlung Kardiologie, Medizinische Hochschule Hannover, Postfach 610180, 03000 Hannover, FRG
Abstract:
Summary A number of animal studies revealed an inhibition or retardation of the progression of atherosclerosis by calcium-antagonists. Encouraged by these studies, a multicenter trial on the progression of coronary artery disease (CAD) in man was initiated testing the antisclerotic effect of nifedipine against placebo in 426 patients with mild to moderate coronary disease over 3 years. All patients underwent coronary angiography before entering the trial and will be restudied after 3 years; changes of the coronary artery lumen size are quantitatively assessed by a computer-assisted system (CAAS). INTACT (International Trial on Antiatherosclerotic Coronary Therapy) is therefore the first randomized prospective study on the progression of CAD based on a quantitated anigraphic control of the coronary system.This report presents the design of this still-ongoing study as well as inclusion and exclusion criteria. The quantitative evaluation of the coronary angiograms and the mode of compliance test are described in detail. A number of baseline data as well as the preliminary results of the quantitative evaluation of the first coronary angiograms are presented.Beside the results on the effect of the calcium-antagonist nifedipine on the progression of CAD, INTACT might also supply information on the antiatherosclerotic potency of other drugs administered additionally (beta-blockers and nitrates) and of HDL-cholesterol.
Keywords:calcium-antagonists  antiatherosclerotic therapy  nifedipine  progression  coronary artery disease
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