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| 法莫替丁大鼠在体小肠吸收动力学研究 | |
| 引用本文： | 张莉,陈大为,李芳久,宋爱华,奎罡波.法莫替丁大鼠在体小肠吸收动力学研究[J].沈阳药科大学学报,2001,18(3):170-172. |
| 作者姓名： | 张莉 陈大为 李芳久 宋爱华 奎罡波 |
| 作者单位： | 1. 沈阳药科大学中药系, 2. 中国医科大学附属第一医院药剂科, 3. 沈阳药科大学分析测试中心, |
| 摘 要： | 应用大鼠在体肠吸收实验方法研究了法莫替丁各肠段的吸收动力学特征。实验表明 :法莫替丁在肠道各部位的吸收速率按十二指肠、空肠、回肠、结肠顺序下降 ,吸收速率常数分别为0 0 5 0 8,0 0 44 6 ,0 0 415 ,0 0 2 87h-1。药物在肠道内的吸收呈现一级吸收动力学过程 ,其吸收机制为被动扩散 |
| 关 键 词： | 法莫替丁 吸收动力学 在体肠吸收 |
| 文章编号： | 1006-2858(2001)03-0170-03 |
| 修稿时间： | 2000年10月27 |
Studies on the absorption kinetics of famotidine in rats'intestines |
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| ZHANG Li,CHEN Da-wei,LI Fang-jiu,SONG Ai-hua,KUI Gang-bo.Studies on the absorption kinetics of famotidine in rats'intestines[J].Journal of Shenyang Pharmaceutical University,2001,18(3):170-172. | |
| Authors: | ZHANG Li CHEN Da-wei LI Fang-jiu SONG Ai-hua KUI Gang-bo |
| Institution: | ZHANG Li 1,CHEN Da wei 1,LI Fang jiu 2,SONG Ai hua 3,KUI Gang bo 1 |
| Abstract: | To explore the absorption mechanism of famotidine from various intestinal segments, the absorption kinetics and permeability rate constants(ka) were investigated by the in situ perfusing method in rats. It was showed that the small intestine was the best absorption segment. The permeability rate constants were 0 050 8 , 0 044 6 , 0 041 5 , 0 028 7 h -1 respectively at duodenum, jejunum, ileum and colon. The absorption mechanism of famotidine was studied at different concentrations. No saturation phenomenon occurred and at the same time, ka was kept unchanged. The results indicated that the absorption of famotidine compiled with the passive transport mechanism and first order kinetics. |
| Keywords: | famotidine absorption kinetics in situ |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |