| 玻璃酸钠抑制骨关节固定造成的兔膝关节退行性改变的实验研究 |
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| 引用本文： | 贺艳丽,王韶进.玻璃酸钠抑制骨关节固定造成的兔膝关节退行性改变的实验研究[J].中国生化药物杂志,1997,18(1):12-15. |
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| 作者姓名： | 贺艳丽 王韶进 |
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| 作者单位： | 山东正大福瑞达制药有限公司!济南，250014(贺艳丽，杨晓红，钱雪，凌沛学)，山东医科大学附属医院(王韶进)，山东医科大学药学系(张天民) |
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| 摘 要： | 采用关节长时间固定的方法造成兔膝关节面软骨的退行性改变的骨关节炎模型，考察关节腔内长期多次注射玻璃酸钠对这种退行性变化的抑制和改善作用。结果表明：玻璃酸钠对处于病变条件下的软骨具有保护作用，可抑制关节长时间固定对兔膝关节面软骨的退行性改变。
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| 关 键 词： | 玻璃酸钠 骨关节固定 退行性改变 |
Protective Effects of Sodium Hyaluronate on Rabbit's Knee Joint Degeneration Induced by Long-Term Immoblization |
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| He Yanli, Yang Xiaohong, Wang Shaojin, Qian Xue, Ling Peixue, Zhang Tianmin.Protective Effects of Sodium Hyaluronate on Rabbit''''s Knee Joint Degeneration Induced by Long-Term Immoblization[J].Chinese Journal of Biochemical Pharmaceutics,1997,18(1):12-15. |
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| Authors: | He Yanli Yang Xiaohong Wang Shaojin Qian Xue Ling Peixue Zhang Tianmin |
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| Institution: | He Yanli; Yang Xiaohong; Wang Shaojin; Qian Xue; Ling Peixue; Zhang Tianmin(Shehong C-.P. Freda Pharm. Co. Ltd. (Jinan 250014 |
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| Abstract: | An experiment was conducted to evaluate the protective effects of sodium hyaluronate (SH) on rabbit's knee joint degeneration induced by long-term immobilization. The results suggested that degenerative changes occured in cartilage and synovial membrane resulted from long-term immobilization could be inhibited or improved by long-term intra-articular injection of SH. |
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| Keywords: | Sodium hyaluronate Immobilization Degeneration |
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