| 高效液相色谱法测定苄达赖氨酸滴眼液的含量和有关物质 |
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| 引用本文： | 金鸽,李雪,王晓明,方成玲,金描真. 高效液相色谱法测定苄达赖氨酸滴眼液的含量和有关物质[J]. 安徽医药, 2010, 14(1): 41-42. DOI: 10.3969/j.issn.1009-6469.2010.01.016 |
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| 作者姓名： | 金鸽 李雪 王晓明 方成玲 金描真 |
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| 作者单位： | 广东药学院药剂学教研室,广东,广州,510006;广东药学院药剂学教研室,广东,广州,510006;广东药学院药剂学教研室,广东,广州,510006;广东药学院药剂学教研室,广东,广州,510006;广东药学院药剂学教研室,广东,广州,510006 |
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| 摘 要： | 目的 测定苄达赖氨酸滴眼液的含量和有关物质。方法采用HPLC法，色谱柱：DiamonsilC18（250mm×4．6mm，5μm）流动相：乙腈：1％醋酸（50：50）。结果苄达赖氨酸对照品在25～250mg·L^-1范围内峰面积与浓度具有良好的线性关系。回归方程为Y=2223X＋538．78，相关系数为R^2=0．9993。结论所用方法简便、准确，可用作苄达赖氨酸及其滴眼液的含量测定及有关物质的检查。
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| 关 键 词： | 高效液相色谱法 苄达赖氨酸滴眼液 稳定性 有关物质 |
Determination of related substance of bendazac lysine eye drops by HPLC |
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| JIN Ge,LI Xue,WANG Xiao-ming,FANG Cheng-ling,JIN Miao-zhen. Determination of related substance of bendazac lysine eye drops by HPLC[J]. Anhui Medical and Pharmaceutical Journal, 2010, 14(1): 41-42. DOI: 10.3969/j.issn.1009-6469.2010.01.016 |
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| Authors: | JIN Ge LI Xue WANG Xiao-ming FANG Cheng-ling JIN Miao-zhen |
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| Affiliation: | Department of Pharmceutics;Guangdong Pharmaceutical University;Guangzhou;Guangdong 510006;China |
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| Abstract: | Aim To determine the related substances of bendazac lysine eye drops.Method HPLC was adopted.The column was Dikma Diamonsil TM C18(250 mm×4.6 mm,5 μm).The mobile phase was acetonitrile-1%HAC(50∶50).Results It had good linearity range from 25 mg·L-1 to 250 mg·L-1.The regression equation is Y=2223X+538.78,and the correlation coefficient is 0.9993.Conclusion The method shows high sensitivity and accuracy,and be used to determine the related substances of bendazac lysine eye drops. |
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| Keywords: | HPLC bendazac lysine eye drops stability related substances |
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